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In\n                    <jats:italic>tax<\/jats:italic>\n                    -expressing cells, the Cdc20-associated anaphase promoting complex (APC\n                    <jats:sup>Cdc20<\/jats:sup>\n                    ), an E3 ubiquitin ligase that controls metaphase to anaphase transition, becomes active before cellular entry into mitosis as evidenced by premature cyclin B1 polyubiquitination and degradation during S\/G\n                    <jats:sub>2<\/jats:sub>\n                    . Consistent with the notion that Tax activates APC\n                    <jats:sup>Cdc20<\/jats:sup>\n                    directly, Tax is found to coimmunoprecipitate with Cdc20 and Cdc27\/APC3. The APC\n                    <jats:sup>Cdc20<\/jats:sup>\n                    activity prematurely activated by Tax remains sensitive to spindle checkpoint inhibition. Unscheduled activation of APC\n                    <jats:sup>Cdc20<\/jats:sup>\n                    by Tax provides an explanation for the mitotic abnormalities in HTLV-I-infected cells and is likely to play an important role in the development of adult T cell leukemia.\n                  <\/jats:p>","DOI":"10.1073\/pnas.0406424101","type":"journal-article","created":{"date-parts":[[2004,12,29]],"date-time":"2004-12-29T00:13:17Z","timestamp":1104279197000},"page":"63-68","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":97,"title":["HTLV-I Tax directly binds the Cdc20-associated anaphase-promoting complex and activates it ahead of schedule"],"prefix":"10.1073","volume":"102","author":[{"given":"Baoying","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Microbiology and Immunology, Uniformed Services University of the Health Sciences, 4301 Jones Bridge Road, Bethesda, MD 20814; and Department of Pharmacology, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sohee","family":"Hong","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, Uniformed Services University of the Health Sciences, 4301 Jones Bridge Road, Bethesda, MD 20814; and Department of Pharmacology, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhanyun","family":"Tang","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, Uniformed Services University of the Health Sciences, 4301 Jones Bridge Road, Bethesda, MD 20814; and Department of Pharmacology, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongtao","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, Uniformed Services University of the Health Sciences, 4301 Jones Bridge Road, Bethesda, MD 20814; and Department of Pharmacology, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chou-Zen","family":"Giam","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, Uniformed Services University of the Health Sciences, 4301 Jones Bridge Road, Bethesda, MD 20814; and Department of Pharmacology, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[2004,12,27]]},"reference":[{"key":"e_1_3_2_1_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-4608(98)00141-1"},{"key":"e_1_3_2_2_2","first-page":"209","volume":"13","year":"1983","unstructured":"Taguchi, H. & Miyoshi, I. 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