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Ras and Wnt signaling pathways play major roles in generating the spatial pattern of cell types and regulate gene expression through a network of transcription factors. One transcription factor (\n                    <jats:italic>lin-29<\/jats:italic>\n                    ) primarily controls the temporal expression pattern. Other transcription factors (\n                    <jats:italic>lin-11<\/jats:italic>\n                    ,\n                    <jats:italic>cog-1<\/jats:italic>\n                    , and\n                    <jats:italic>egl-38<\/jats:italic>\n                    ) act in combination to control cell-type-specific gene expression. The complexity of the network arises in part because of the dynamic nature of gene expression, in part because of the presence of seven cell types, and also because there are multiple regulatory paths for gene expression within each cell type.\n                  <\/jats:p>","DOI":"10.1073\/pnas.0408122102","type":"journal-article","created":{"date-parts":[[2005,3,4]],"date-time":"2005-03-04T20:24:27Z","timestamp":1109967867000},"page":"4972-4977","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":56,"title":["Transcriptional network underlying Caenorhabditis elegans vulval development"],"prefix":"10.1073","volume":"102","author":[{"given":"Takao","family":"Inoue","sequence":"first","affiliation":[{"name":"Division of Biology and Howard Hughes Medical Institute, California Institute of Technology, Pasadena, CA 91125"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minqin","family":"Wang","sequence":"additional","affiliation":[{"name":"Division of Biology and Howard Hughes Medical Institute, California Institute of Technology, Pasadena, CA 91125"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ted O.","family":"Ririe","sequence":"additional","affiliation":[{"name":"Division of Biology and Howard Hughes Medical Institute, California Institute of Technology, Pasadena, CA 91125"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jolene S.","family":"Fernandes","sequence":"additional","affiliation":[{"name":"Division of Biology and Howard Hughes Medical Institute, California Institute of Technology, Pasadena, CA 91125"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul W.","family":"Sternberg","sequence":"additional","affiliation":[{"name":"Division of Biology and Howard Hughes Medical Institute, California Institute of Technology, Pasadena, CA 91125"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[2005,3,4]]},"reference":[{"key":"e_1_3_2_1_2","unstructured":"Wood W. 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