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The defect was not observed in mice with an endothelium-restricted deficiency of the protein but was still detectable in mice transplanted with bone marrow from\n                    <jats:italic>JAM-A<\/jats:italic>\n                    <jats:sup>-\/-<\/jats:sup>\n                    donors. Microscopic examination of mesenteric and heart microvasculature of\n                    <jats:italic>JAM-A<\/jats:italic>\n                    <jats:sup>-\/-<\/jats:sup>\n                    mice showed high numbers of PMN adherent on the endothelium or entrapped between endothelial cells and the basement membrane.\n                    <jats:italic>In vitro<\/jats:italic>\n                    , in the absence of\n                    <jats:italic>JAM-A<\/jats:italic>\n                    , PMN adhered more efficiently to endothelial cells and basement membrane proteins, and their polarized movement was strongly reduced. This paper describes a nonredundant role of JAM-A in controlling PMN diapedesis through the vessel wall.\n                  <\/jats:p>","DOI":"10.1073\/pnas.0500147102","type":"journal-article","created":{"date-parts":[[2005,7,18]],"date-time":"2005-07-18T20:33:58Z","timestamp":1121718838000},"page":"10634-10639","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":105,"title":["Junctional adhesion molecule-A-deficient polymorphonuclear cells show reduced diapedesis in peritonitis and heart ischemia-reperfusion injury"],"prefix":"10.1073","volume":"102","author":[{"given":"Monica","family":"Corada","sequence":"first","affiliation":[{"name":"Fondazione Italiana per la Ricerca sul Cancro, Institute of Molecular Oncology, 20139 Milan, Italy; Mario Negri Institute for Pharmacological Research, 20157 Milan, Italy; Consorzio Microscopy and Image Analysis and Department of Neuroscience, University of Milano-Bicocca, 20052 Monza, Italy; Istituto Europeo di Oncologia, 20141 Milan, Italy; University of Texas Southwestern Medical Center, Dallas, TX 75390; Department of Medicine, New York Medical College, Valhalla, NY 10595; and Department of..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefano","family":"Chimenti","sequence":"additional","affiliation":[{"name":"Fondazione Italiana per la Ricerca sul Cancro, Institute of Molecular Oncology, 20139 Milan, Italy; Mario Negri Institute for Pharmacological Research, 20157 Milan, Italy; Consorzio Microscopy and Image Analysis and Department of Neuroscience, University of Milano-Bicocca, 20052 Monza, Italy; Istituto Europeo di Oncologia, 20141 Milan, Italy; University of Texas Southwestern Medical Center, Dallas, TX 75390; Department of Medicine, New York Medical College, Valhalla, NY 10595; and Department of..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Rosaria","family":"Cera","sequence":"additional","affiliation":[{"name":"Fondazione Italiana per la Ricerca sul Cancro, Institute of Molecular Oncology, 20139 Milan, Italy; 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