{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T12:23:29Z","timestamp":1791203009191,"version":"4.2.0"},"reference-count":40,"publisher":"National Academy of Sciences","issue":"10","content-domain":{"domain":["www.pnas.org"],"crossmark-restriction":true},"short-container-title":["Proc. Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2005,3,8]]},"abstract":"<jats:p>\n                    We show that the microRNA miR-155 can be processed from sequences present in\n                    <jats:italic>BIC<\/jats:italic>\n                    RNA, a spliced and polyadenylated but non-protein-coding RNA that accumulates in lymphoma cells. The precursor of miR-155 is likely a transient spliced or unspliced nuclear\n                    <jats:italic>BIC<\/jats:italic>\n                    transcript rather than accumulated\n                    <jats:italic>BIC<\/jats:italic>\n                    RNA, which is primarily cytoplasmic. By using a sensitive and quantitative assay, we find that clinical isolates of several types of B cell lymphomas, including diffuse large B cell lymphoma (DLBCL), have 10- to 30-fold higher copy numbers of miR-155 than do normal circulating B cells. Similarly, the quantities of\n                    <jats:italic>BIC<\/jats:italic>\n                    RNA are elevated in lymphoma cells, but ratios of the amounts of the two RNAs are not constant, suggesting that the level of miR-155 is controlled by transcription and processing. Significantly higher levels of miR-155 are present in DLBCLs with an activated B cell phenotype than with the germinal center phenotype. Because patients with activated B cell-type DLBCL have a poorer clinical prognosis, quantification of this microRNA may be diagnostically useful.\n                  <\/jats:p>","DOI":"10.1073\/pnas.0500613102","type":"journal-article","created":{"date-parts":[[2005,2,28]],"date-time":"2005-02-28T20:24:54Z","timestamp":1109622294000},"page":"3627-3632","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":1103,"title":["Accumulation of miR-155 and\n                    <i>BIC<\/i>\n                    RNA in human B cell lymphomas"],"prefix":"10.1073","volume":"102","author":[{"given":"Peggy S.","family":"Eis","sequence":"first","affiliation":[{"name":"Department of Biomolecular Chemistry, University of Wisconsin Medical School, 1300 University Avenue, Madison, WI 53706; and Department of Pathology and Laboratory Medicine, The Joan and Sanford I. 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