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The L1 structure reveals a hydrophobic cavity located adjacent to its N terminus. The cavity would be capable of shielding the myristate moiety, which is essential for virion assembly. The structure of L1 is a step in the elucidation of molecular mechanisms common to all poxviruses that may stimulate the design of safer vaccines and new antipoxvirus drugs.<\/jats:p>","DOI":"10.1073\/pnas.0501103102","type":"journal-article","created":{"date-parts":[[2005,3,10]],"date-time":"2005-03-10T21:54:28Z","timestamp":1110491668000},"page":"4240-4245","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":89,"title":["The 1.51-\u00c5 structure of the poxvirus L1 protein, a target of potent neutralizing antibodies"],"prefix":"10.1073","volume":"102","author":[{"given":"Hua-Poo","family":"Su","sequence":"first","affiliation":[{"name":"Structural Biology Section, Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 12441 Parklawn Drive, Rockville, MD 20852; Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892; and Department of Biochemistry and Molecular Biology, University of Massachusetts, 1021K LGRT-B, 710 North Pleasant Street, Amherst, MA 01003"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Scott C.","family":"Garman","sequence":"additional","affiliation":[{"name":"Structural Biology Section, Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 12441 Parklawn Drive, Rockville, MD 20852; Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892; and Department of Biochemistry and Molecular Biology, University of Massachusetts, 1021K LGRT-B, 710 North Pleasant Street, Amherst, MA 01003"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timothy J.","family":"Allison","sequence":"additional","affiliation":[{"name":"Structural Biology Section, Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 12441 Parklawn Drive, Rockville, MD 20852; Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892; and Department of Biochemistry and Molecular Biology, University of Massachusetts, 1021K LGRT-B, 710 North Pleasant Street, Amherst, MA 01003"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christiana","family":"Fogg","sequence":"additional","affiliation":[{"name":"Structural Biology Section, Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 12441 Parklawn Drive, Rockville, MD 20852; Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892; and Department of Biochemistry and Molecular Biology, University of Massachusetts, 1021K LGRT-B, 710 North Pleasant Street, Amherst, MA 01003"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernard","family":"Moss","sequence":"additional","affiliation":[{"name":"Structural Biology Section, Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 12441 Parklawn Drive, Rockville, MD 20852; Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892; and Department of Biochemistry and Molecular Biology, University of Massachusetts, 1021K LGRT-B, 710 North Pleasant Street, Amherst, MA 01003"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David N.","family":"Garboczi","sequence":"additional","affiliation":[{"name":"Structural Biology Section, Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 12441 Parklawn Drive, Rockville, MD 20852; Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892; and Department of Biochemistry and Molecular Biology, University of Massachusetts, 1021K LGRT-B, 710 North Pleasant Street, Amherst, MA 01003"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[2005,3,10]]},"reference":[{"key":"e_1_3_2_1_2","unstructured":"Fields B. 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