{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T20:37:41Z","timestamp":1791664661361,"version":"4.3.4"},"reference-count":41,"publisher":"National Academy of Sciences","issue":"14","content-domain":{"domain":["www.pnas.org"],"crossmark-restriction":true},"short-container-title":["Proc. Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2005,4,5]]},"abstract":"<jats:p>\n                    Mutations of the\n                    <jats:italic>DJ-1<\/jats:italic>\n                    (PARK7) gene are linked to familial Parkinson's disease. We used gene targeting to generate DJ-1-deficient mice that were viable, fertile, and showed no gross anatomical or neuronal abnormalities. Dopaminergic neuron numbers in the\n                    <jats:italic>substantia nigra<\/jats:italic>\n                    and fiber densities and dopamine levels in the striatum were normal. However, DJ-1\u2013\/\u2013 mice showed hypolocomotion when subjected to amphetamine challenge and increased striatal denervation and dopaminergic neuron loss induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyrindine. DJ-1\u2013\/\u2013embryonic cortical neurons showed increased sensitivity to oxidative, but not nonoxidative, insults. Restoration of DJ-1 expression to DJ-1\u2013\/\u2013 mice or cells via adenoviral vector delivery mitigated all phenotypes. WT mice that received adenoviral delivery of DJ-1 resisted 1-methyl-4-phenyl-1,2,3,6-tetrahydropyrindine-induced striatal damage, and neurons overexpressing DJ-1 were protected from oxidative stress\n                    <jats:italic>in vitro<\/jats:italic>\n                    . Thus, DJ-1 protects against neuronal oxidative stress, and loss of DJ-1 may lead to Parkinson's disease by conferring hypersensitivity to dopaminergic insults.\n                  <\/jats:p>","DOI":"10.1073\/pnas.0501282102","type":"journal-article","created":{"date-parts":[[2005,3,22]],"date-time":"2005-03-22T20:24:48Z","timestamp":1111523088000},"page":"5215-5220","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":619,"title":["Hypersensitivity of DJ-1-deficient mice to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyrindine (MPTP) and oxidative stress"],"prefix":"10.1073","volume":"102","author":[{"given":"Raymond H.","family":"Kim","sequence":"first","affiliation":[{"name":"Campbell Family Institute for Breast Cancer Research, Advanced Medical Discovery Institute, Ontario Cancer Institute and Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada M5G 2C1; Neuroscience Research Group, Ottawa Health Research Institute, University of Ottawa, Ottawa, ON, Canada K1H 8M5; Institute for Neuroscience, Carleton University, Ottawa, ON, Canada K1H 6N5; enGene Incorporated, Vancouver, BC, Canada V6T 1Z3; Division of Applied and Interventional Research,..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrice D.","family":"Smith","sequence":"additional","affiliation":[{"name":"Campbell Family Institute for Breast Cancer Research, Advanced Medical Discovery Institute, Ontario Cancer Institute and Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada M5G 2C1; Neuroscience Research Group, Ottawa Health Research Institute, University of Ottawa, Ottawa, ON, Canada K1H 8M5; Institute for Neuroscience, Carleton University, Ottawa, ON, Canada K1H 6N5; enGene Incorporated, Vancouver, BC, Canada V6T 1Z3; Division of Applied and Interventional Research,..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hossein","family":"Aleyasin","sequence":"additional","affiliation":[{"name":"Campbell Family Institute for Breast Cancer Research, Advanced Medical Discovery Institute, Ontario Cancer Institute and Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada M5G 2C1; Neuroscience Research Group, Ottawa Health Research Institute, University of Ottawa, Ottawa, ON, Canada K1H 8M5; Institute for Neuroscience, Carleton University, Ottawa, ON, Canada K1H 6N5; enGene Incorporated, Vancouver, BC, Canada V6T 1Z3; Division of Applied and Interventional Research,..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shawn","family":"Hayley","sequence":"additional","affiliation":[{"name":"Campbell Family Institute for Breast Cancer Research, Advanced Medical Discovery Institute, Ontario Cancer Institute and Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada M5G 2C1; Neuroscience Research Group, Ottawa Health Research Institute, University of Ottawa, Ottawa, ON, Canada K1H 8M5; Institute for Neuroscience, Carleton University, Ottawa, ON, Canada K1H 6N5; enGene Incorporated, Vancouver, BC, Canada V6T 1Z3; Division of Applied and Interventional Research,..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew P.","family":"Mount","sequence":"additional","affiliation":[{"name":"Campbell Family Institute for Breast Cancer Research, Advanced Medical Discovery Institute, Ontario Cancer Institute and Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada M5G 2C1; Neuroscience Research Group, Ottawa Health Research Institute, University of Ottawa, Ottawa, ON, Canada K1H 8M5; Institute for Neuroscience, Carleton University, Ottawa, ON, Canada K1H 6N5; enGene Incorporated, Vancouver, BC, Canada V6T 1Z3; Division of Applied and Interventional Research,..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Scott","family":"Pownall","sequence":"additional","affiliation":[{"name":"Campbell Family Institute for Breast Cancer Research, Advanced Medical Discovery Institute, Ontario Cancer Institute and Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada M5G 2C1; Neuroscience Research Group, Ottawa Health Research Institute, University of Ottawa, Ottawa, ON, Canada K1H 8M5; Institute for Neuroscience, Carleton University, Ottawa, ON, Canada K1H 6N5; enGene Incorporated, Vancouver, BC, Canada V6T 1Z3; Division of Applied and Interventional Research,..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew","family":"Wakeham","sequence":"additional","affiliation":[{"name":"Campbell Family Institute for Breast Cancer Research, Advanced Medical Discovery Institute, Ontario Cancer Institute and Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada M5G 2C1; Neuroscience Research Group, Ottawa Health Research Institute, University of Ottawa, Ottawa, ON, Canada K1H 8M5; Institute for Neuroscience, Carleton University, Ottawa, ON, Canada K1H 6N5; enGene Incorporated, Vancouver, BC, Canada V6T 1Z3; Division of Applied and Interventional Research,..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annick J.","family":"You-Ten","sequence":"additional","affiliation":[{"name":"Campbell Family Institute for Breast Cancer Research, Advanced Medical Discovery Institute, Ontario Cancer Institute and Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada M5G 2C1; Neuroscience Research Group, Ottawa Health Research Institute, University of Ottawa, Ottawa, ON, Canada K1H 8M5; Institute for Neuroscience, Carleton University, Ottawa, ON, Canada K1H 6N5; enGene Incorporated, Vancouver, BC, Canada V6T 1Z3; Division of Applied and Interventional Research,..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suneil K.","family":"Kalia","sequence":"additional","affiliation":[{"name":"Campbell Family Institute for Breast Cancer Research, Advanced Medical Discovery Institute, Ontario Cancer Institute and Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada M5G 2C1; Neuroscience Research Group, Ottawa Health Research Institute, University of Ottawa, Ottawa, ON, Canada K1H 8M5; Institute for Neuroscience, Carleton University, Ottawa, ON, Canada K1H 6N5; enGene Incorporated, Vancouver, BC, Canada V6T 1Z3; Division of Applied and Interventional Research,..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick","family":"Horne","sequence":"additional","affiliation":[{"name":"Campbell Family Institute for Breast Cancer Research, Advanced Medical Discovery Institute, Ontario Cancer Institute and Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada M5G 2C1; Neuroscience Research Group, Ottawa Health Research Institute, University of Ottawa, Ottawa, ON, Canada K1H 8M5; Institute for Neuroscience, Carleton University, Ottawa, ON, Canada K1H 6N5; enGene Incorporated, Vancouver, BC, Canada V6T 1Z3; Division of Applied and Interventional Research,..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Westaway","sequence":"additional","affiliation":[{"name":"Campbell Family Institute for Breast Cancer Research, Advanced Medical Discovery Institute, Ontario Cancer Institute and Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada M5G 2C1; Neuroscience Research Group, Ottawa Health Research Institute, University of Ottawa, Ottawa, ON, Canada K1H 8M5; Institute for Neuroscience, Carleton University, Ottawa, ON, Canada K1H 6N5; enGene Incorporated, Vancouver, BC, Canada V6T 1Z3; Division of Applied and Interventional Research,..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andres M.","family":"Lozano","sequence":"additional","affiliation":[{"name":"Campbell Family Institute for Breast Cancer Research, Advanced Medical Discovery Institute, Ontario Cancer Institute and Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada M5G 2C1; Neuroscience Research Group, Ottawa Health Research Institute, University of Ottawa, Ottawa, ON, Canada K1H 8M5; Institute for Neuroscience, Carleton University, Ottawa, ON, Canada K1H 6N5; enGene Incorporated, Vancouver, BC, Canada V6T 1Z3; Division of Applied and Interventional Research,..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hymie","family":"Anisman","sequence":"additional","affiliation":[{"name":"Campbell Family Institute for Breast Cancer Research, Advanced Medical Discovery Institute, Ontario Cancer Institute and Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada M5G 2C1; 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