{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T17:28:15Z","timestamp":1791221295412,"version":"4.1.0"},"reference-count":40,"publisher":"National Academy of Sciences","issue":"21","content-domain":{"domain":["www.pnas.org"],"crossmark-restriction":true},"short-container-title":["Proc. Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2005,5,24]]},"abstract":"<jats:p>\n                    A characteristic of the secondary response of CD8\n                    <jats:sup>+<\/jats:sup>\n                    T cells that distinguishes it from the primary response is the generation of greater numbers of effector cells. Because effector CD8\n                    <jats:sup>+<\/jats:sup>\n                    T cells are derived from a pool of less differentiated, replicating cells in secondary lymphoid organs, and because IL-2 mediates effector differentiation, the enhanced secondary response may reflect the enlargement of this generative pool by the transient repression of IL-2-mediated differentiation. We have examined for this function the transcriptional repressor BCL6b, a homologue of BCL6 that represses IL-2-induced B cell differentiation. BCL6b is expressed in a small subset of antigen-experienced CD8\n                    <jats:sup>+<\/jats:sup>\n                    T cells. Ectopic expression of BCL6b in CD8\n                    <jats:sup>+<\/jats:sup>\n                    T cells diminishes their growth in response to IL-2\n                    <jats:italic>in vitro<\/jats:italic>\n                    . Female mice in which the\n                    <jats:italic>BCL6b<\/jats:italic>\n                    gene has been interrupted have normal primary responses of CD8\n                    <jats:sup>+<\/jats:sup>\n                    T cells to infection with vaccinia expressing the H-Y epitope, Uty, but Uty-specific, BCL6b\n                    <jats:sup>\u2013\/\u2013<\/jats:sup>\n                    , memory CD8\n                    <jats:sup>+<\/jats:sup>\n                    T cells have diminished recall proliferative responses to this epitope\n                    <jats:italic>in vitro<\/jats:italic>\n                    . BCL6b\n                    <jats:sup>\u2013\/\u2013<\/jats:sup>\n                    mice also have normal primary CD8\n                    <jats:sup>+<\/jats:sup>\n                    T cell responses to influenza infection, but nucleoprotein peptide-specific, BCL6b\n                    <jats:sup>\u2013\/\u2013<\/jats:sup>\n                    , memory CD8\n                    <jats:sup>+<\/jats:sup>\n                    T cells have a cell autonomous defect in the number of effector cells generated in response to reinfection. Therefore, BCL6b is required for the enhanced magnitude of the secondary response of memory CD8\n                    <jats:sup>+<\/jats:sup>\n                    T cells.\n                  <\/jats:p>","DOI":"10.1073\/pnas.0501585102","type":"journal-article","created":{"date-parts":[[2005,4,15]],"date-time":"2005-04-15T20:25:31Z","timestamp":1113596731000},"page":"7418-7425","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":78,"title":["BCL6b mediates the enhanced magnitude of the secondary response of memory CD8\n                    <sup>+<\/sup>\n                    T lymphocytes"],"prefix":"10.1073","volume":"102","author":[{"given":"Peter M.","family":"Manders","sequence":"first","affiliation":[{"name":"Wellcome Trust Immunology Unit, Department of Medicine, University of Cambridge, Medical Research Council Centre, Hills Road, Cambridge CB2 2QH, United Kingdom; Cancer Research UK Tumor Immunology Unit, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, Headley Way, Oxford OX3 9DS, United Kingdom; Section of Immunobiology, Yale Medical School, 300 Cedar Street, TAC S641, P.O. Box 208011, New Haven, CT 06520-8011; and Emory Vaccine Center and Department of Microbiology and..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patricia J.","family":"Hunter","sequence":"additional","affiliation":[{"name":"Wellcome Trust Immunology Unit, Department of Medicine, University of Cambridge, Medical Research Council Centre, Hills Road, Cambridge CB2 2QH, United Kingdom; Cancer Research UK Tumor Immunology Unit, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, Headley Way, Oxford OX3 9DS, United Kingdom; Section of Immunobiology, Yale Medical School, 300 Cedar Street, TAC S641, P.O. Box 208011, New Haven, CT 06520-8011; and Emory Vaccine Center and Department of Microbiology and..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aino I.","family":"Telaranta","sequence":"additional","affiliation":[{"name":"Wellcome Trust Immunology Unit, Department of Medicine, University of Cambridge, Medical Research Council Centre, Hills Road, Cambridge CB2 2QH, United Kingdom; Cancer Research UK Tumor Immunology Unit, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, Headley Way, Oxford OX3 9DS, United Kingdom; Section of Immunobiology, Yale Medical School, 300 Cedar Street, TAC S641, P.O. Box 208011, New Haven, CT 06520-8011; and Emory Vaccine Center and Department of Microbiology and..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James M.","family":"Carr","sequence":"additional","affiliation":[{"name":"Wellcome Trust Immunology Unit, Department of Medicine, University of Cambridge, Medical Research Council Centre, Hills Road, Cambridge CB2 2QH, United Kingdom; Cancer Research UK Tumor Immunology Unit, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, Headley Way, Oxford OX3 9DS, United Kingdom; Section of Immunobiology, Yale Medical School, 300 Cedar Street, TAC S641, P.O. Box 208011, New Haven, CT 06520-8011; and Emory Vaccine Center and Department of Microbiology and..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer L.","family":"Marshall","sequence":"additional","affiliation":[{"name":"Wellcome Trust Immunology Unit, Department of Medicine, University of Cambridge, Medical Research Council Centre, Hills Road, Cambridge CB2 2QH, United Kingdom; Cancer Research UK Tumor Immunology Unit, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, Headley Way, Oxford OX3 9DS, United Kingdom; Section of Immunobiology, Yale Medical School, 300 Cedar Street, TAC S641, P.O. Box 208011, New Haven, CT 06520-8011; and Emory Vaccine Center and Department of Microbiology and..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marlene","family":"Carrasco","sequence":"additional","affiliation":[{"name":"Wellcome Trust Immunology Unit, Department of Medicine, University of Cambridge, Medical Research Council Centre, Hills Road, Cambridge CB2 2QH, United Kingdom; Cancer Research UK Tumor Immunology Unit, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, Headley Way, Oxford OX3 9DS, United Kingdom; Section of Immunobiology, Yale Medical School, 300 Cedar Street, TAC S641, P.O. Box 208011, New Haven, CT 06520-8011; and Emory Vaccine Center and Department of Microbiology and..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yusuke","family":"Murakami","sequence":"additional","affiliation":[{"name":"Wellcome Trust Immunology Unit, Department of Medicine, University of Cambridge, Medical Research Council Centre, Hills Road, Cambridge CB2 2QH, United Kingdom; Cancer Research UK Tumor Immunology Unit, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, Headley Way, Oxford OX3 9DS, United Kingdom; Section of Immunobiology, Yale Medical School, 300 Cedar Street, TAC S641, P.O. Box 208011, New Haven, CT 06520-8011; and Emory Vaccine Center and Department of Microbiology and..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael J.","family":"Palmowski","sequence":"additional","affiliation":[{"name":"Wellcome Trust Immunology Unit, Department of Medicine, University of Cambridge, Medical Research Council Centre, Hills Road, Cambridge CB2 2QH, United Kingdom; Cancer Research UK Tumor Immunology Unit, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, Headley Way, Oxford OX3 9DS, United Kingdom; Section of Immunobiology, Yale Medical School, 300 Cedar Street, TAC S641, P.O. Box 208011, New Haven, CT 06520-8011; and Emory Vaccine Center and Department of Microbiology and..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincenzo","family":"Cerundolo","sequence":"additional","affiliation":[{"name":"Wellcome Trust Immunology Unit, Department of Medicine, University of Cambridge, Medical Research Council Centre, Hills Road, Cambridge CB2 2QH, United Kingdom; Cancer Research UK Tumor Immunology Unit, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, Headley Way, Oxford OX3 9DS, United Kingdom; Section of Immunobiology, Yale Medical School, 300 Cedar Street, TAC S641, P.O. Box 208011, New Haven, CT 06520-8011; and Emory Vaccine Center and Department of Microbiology and..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan M.","family":"Kaech","sequence":"additional","affiliation":[{"name":"Wellcome Trust Immunology Unit, Department of Medicine, University of Cambridge, Medical Research Council Centre, Hills Road, Cambridge CB2 2QH, United Kingdom; Cancer Research UK Tumor Immunology Unit, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, Headley Way, Oxford OX3 9DS, United Kingdom; Section of Immunobiology, Yale Medical School, 300 Cedar Street, TAC S641, P.O. 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Box 208011, New Haven, CT 06520-8011; and Emory Vaccine Center and Department of Microbiology and..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Douglas T.","family":"Fearon","sequence":"additional","affiliation":[{"name":"Wellcome Trust Immunology Unit, Department of Medicine, University of Cambridge, Medical Research Council Centre, Hills Road, Cambridge CB2 2QH, United Kingdom; Cancer Research UK Tumor Immunology Unit, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, Headley Way, Oxford OX3 9DS, United Kingdom; Section of Immunobiology, Yale Medical School, 300 Cedar Street, TAC S641, P.O. 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