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We found that the peptide signal spore differentiation factor 2 (SDF-2) is processed from acyl-CoA binding protein, AcbA. The mammalian homolog of AcbA is processed to diazepam binding inhibitor that binds to the GABA\n                    <jats:sub>A<\/jats:sub>\n                    receptor in the brain and to peripheral 1,4 benzodiazepine receptors. Although\n                    <jats:italic>Dictyostelium<\/jats:italic>\n                    has neither GABA\n                    <jats:sub>A<\/jats:sub>\n                    nor peripheral-type benzodiazepine receptors, we find that both a diazepam binding inhibitor peptide and diazepam (Valium) can mimic SDF-2 in a\n                    <jats:italic>Dictyostelium<\/jats:italic>\n                    bioassay. Mutants lacking AcbA sporulate well only when developed in chimeras with WT cells. Using a yeast system we show that ligand binding to the SDF-2 receptor histidine kinase, DhkA, inhibits phosphorelay, which can account for its ability to induce rapid sporulation.\n                  <\/jats:p>","DOI":"10.1073\/pnas.0501820102","type":"journal-article","created":{"date-parts":[[2005,5,16]],"date-time":"2005-05-16T20:35:10Z","timestamp":1116275710000},"page":"7607-7611","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":85,"title":["Peptide signaling during terminal differentiation of\n                    <i>Dictyostelium<\/i>"],"prefix":"10.1073","volume":"102","author":[{"given":"Christophe","family":"Anjard","sequence":"first","affiliation":[{"name":"Center for Molecular Genetics, Division of Biological Sciences, University of California at San Diego, La Jolla, CA 92093-0368"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William F.","family":"Loomis","sequence":"additional","affiliation":[{"name":"Center for Molecular Genetics, Division of Biological Sciences, University of California at San Diego, La Jolla, CA 92093-0368"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[2005,5,16]]},"reference":[{"key":"e_1_3_2_1_2","first-page":"2891","volume":"120","year":"1994","unstructured":"Richardson, D. 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