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We show that inhibition of endogenous Siah-1 stabilizes and activates \u03b2-catenin in B cells. The principal Epstein\u2013Barr virus oncoprotein, latent membrane protein 1, is involved in \u03b2-catenin up-regulation, and expression of latent membrane protein 1 in B lymphoma cells is associated with decreased Siah-1 RNA and protein levels. Thus, we demonstrate the significance of the endogenous Siah-1-dependent ubiquitin\/proteasome pathway for \u03b2-catenin degradation in malignant human cells and its regulation by a viral oncogene.<\/jats:p>","DOI":"10.1073\/pnas.0504054102","type":"journal-article","created":{"date-parts":[[2005,12,12]],"date-time":"2005-12-12T21:03:36Z","timestamp":1134421416000},"page":"18431-18436","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":48,"title":["Up-regulation of \u03b2-catenin by a viral oncogene correlates with inhibition of the seven in absentia homolog 1 in B lymphoma cells"],"prefix":"10.1073","volume":"102","author":[{"given":"Kyung Lib","family":"Jang","sequence":"first","affiliation":[{"name":"Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC 27599-7295; and Division of Biological Sciences, Pusan National University, Busan 609-735, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia","family":"Shackelford","sequence":"additional","affiliation":[{"name":"Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC 27599-7295; and Division of Biological Sciences, Pusan National University, Busan 609-735, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"So Young","family":"Seo","sequence":"additional","affiliation":[{"name":"Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC 27599-7295; and Division of Biological Sciences, Pusan National University, Busan 609-735, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph S.","family":"Pagano","sequence":"additional","affiliation":[{"name":"Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC 27599-7295; and Division of Biological Sciences, Pusan National University, Busan 609-735, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[2005,12,12]]},"reference":[{"key":"e_1_3_2_1_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0960-9822(01)00473-0"},{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.287.5458.1606"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.200402153"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1094291"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0960-9822(02)00969-7"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1006\/bbrc.1999.1860"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tips.2004.07.006"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1097-2765(01)00241-6"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1097-2765(01)00242-8"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.19.1.724"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0534783100"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M306407200"},{"key":"e_1_3_2_13_2","unstructured":"Rickinson A. & Kieff E. 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