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In addition, BAX- and BAK-deficient B cells display defective cell cycle progression to B cell receptor crosslinking and lipopolysaccharide, but not to CpG\u2013DNA. Furthermore, inducible deletion of\n                    <jats:italic>Bax<\/jats:italic>\n                    and\n                    <jats:italic>Bak<\/jats:italic>\n                    in adult mice results in the development of severe autoimmune disease.\n                  <\/jats:p>","DOI":"10.1073\/pnas.0504783102","type":"journal-article","created":{"date-parts":[[2005,7,29]],"date-time":"2005-07-29T20:34:18Z","timestamp":1122669258000},"page":"11272-11277","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":200,"title":["Essential role of BAX,BAK in B cell homeostasis and prevention of autoimmune disease"],"prefix":"10.1073","volume":"102","author":[{"given":"Osamu","family":"Takeuchi","sequence":"first","affiliation":[{"name":"Howard Hughes Medical Institute, Dana\u2013Farber Cancer Institute, and Departments of Pathology and Medicine, Harvard Medical School, Boston, MA 02115; Department of Host Defense, Research Institute for Microbial Diseases, Osaka University, Suita, Osaka 565-0871 Japan; and Department of Internal Medicine, Virginia Commonwealth University, Massey Cancer Center, Richmond, VA 23298"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jill","family":"Fisher","sequence":"additional","affiliation":[{"name":"Howard Hughes Medical Institute, Dana\u2013Farber Cancer Institute, and Departments of Pathology and Medicine, Harvard Medical School, Boston, MA 02115; Department of Host Defense, Research Institute for Microbial Diseases, Osaka University, Suita, Osaka 565-0871 Japan; and Department of Internal Medicine, Virginia Commonwealth University, Massey Cancer Center, Richmond, VA 23298"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heikyung","family":"Suh","sequence":"additional","affiliation":[{"name":"Howard Hughes Medical Institute, Dana\u2013Farber Cancer Institute, and Departments of Pathology and Medicine, Harvard Medical School, Boston, MA 02115; Department of Host Defense, Research Institute for Microbial Diseases, Osaka University, Suita, Osaka 565-0871 Japan; and Department of Internal Medicine, Virginia Commonwealth University, Massey Cancer Center, Richmond, VA 23298"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hisashi","family":"Harada","sequence":"additional","affiliation":[{"name":"Howard Hughes Medical Institute, Dana\u2013Farber Cancer Institute, and Departments of Pathology and Medicine, Harvard Medical School, Boston, MA 02115; Department of Host Defense, Research Institute for Microbial Diseases, Osaka University, Suita, Osaka 565-0871 Japan; and Department of Internal Medicine, Virginia Commonwealth University, Massey Cancer Center, Richmond, VA 23298"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbara A.","family":"Malynn","sequence":"additional","affiliation":[{"name":"Howard Hughes Medical Institute, Dana\u2013Farber Cancer Institute, and Departments of Pathology and Medicine, Harvard Medical School, Boston, MA 02115; Department of Host Defense, Research Institute for Microbial Diseases, Osaka University, Suita, Osaka 565-0871 Japan; and Department of Internal Medicine, Virginia Commonwealth University, Massey Cancer Center, Richmond, VA 23298"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stanley J.","family":"Korsmeyer","sequence":"additional","affiliation":[{"name":"Howard Hughes Medical Institute, Dana\u2013Farber Cancer Institute, and Departments of Pathology and Medicine, Harvard Medical School, Boston, MA 02115; Department of Host Defense, Research Institute for Microbial Diseases, Osaka University, Suita, Osaka 565-0871 Japan; and Department of Internal Medicine, Virginia Commonwealth University, Massey Cancer Center, Richmond, VA 23298"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[2005,7,29]]},"reference":[{"key":"e_1_3_2_1_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.immunol.19.1.595"},{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.immunol.21.120601.141029"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0952-7915(00)00205-3"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-065X.2003.00036.x"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.0105-2896.2004.0108.x"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(02)00704-3"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1038\/ni0503-410"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(04)00046-7"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1059108"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1097-2765(01)00320-3"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1535-6108(02)00127-7"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2005.02.003"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(89)90174-8"},{"key":"e_1_3_2_14_2","first-page":"175","volume":"166","year":"1990","unstructured":"Strasser, A., Harris, A. 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