{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,18]],"date-time":"2026-10-18T02:09:30Z","timestamp":1792289370914,"version":"4.4.0"},"reference-count":29,"publisher":"National Academy of Sciences","issue":"43","content-domain":{"domain":["www.pnas.org"],"crossmark-restriction":true},"short-container-title":["Proc. Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2005,10,25]]},"abstract":"<jats:p>\n                    Chronic microbial infections are associated with fibrotic and inflammatory reactions known as granulomas showing similarities to wound-healing and tissue repair processes. We have previously mapped three leishmaniasis susceptibility loci, designated\n                    <jats:italic>lmr1<\/jats:italic>\n                    , -\n                    <jats:italic>2<\/jats:italic>\n                    , and -\n                    <jats:italic>3<\/jats:italic>\n                    , which exert their effect independently of T cell immune responses. Here, we show that the wound repair response is critically important for the rapid cure in murine cutaneous leishmaniasis caused by\n                    <jats:italic>Leishmania major<\/jats:italic>\n                    . Mice congenic for leishmaniasis resistance loci, which cured their lesions more rapidly than their susceptible parents, also expressed differentially genes involved in tissue repair, laid down more ordered collagen fibers, and healed punch biopsy wounds more rapidly. Fibroblast monolayers from these mice repaired\n                    <jats:italic>in vitro<\/jats:italic>\n                    wounds faster, and this process was accelerated by supernatants from infected macrophages. Because these effects are independent of T cell-mediated immunity, we conclude that the rate of wound healing is likely to be an important component of innate immunity involved in resistance to cutaneous leishmaniasis.\n                  <\/jats:p>","DOI":"10.1073\/pnas.0505630102","type":"journal-article","created":{"date-parts":[[2005,10,13]],"date-time":"2005-10-13T20:33:29Z","timestamp":1129235609000},"page":"15551-15556","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":49,"title":["The wound repair response controls outcome to cutaneous leishmaniasis"],"prefix":"10.1073","volume":"102","author":[{"given":"Anuratha","family":"Sakthianandeswaren","sequence":"first","affiliation":[{"name":"Genetics and Bioinformatics Division and Department of Infection and Immunity, The Walter and Eliza Hall Institute, 1G Royal Parade, Parkville, Victoria 3050, Australia; Department of Medical Biology, University of Melbourne, Parkville, Victoria 3010, Australia; and Menzies Research Institute, 17 Liverpool Street, Hobart, Tasmania 7000, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Colleen M.","family":"Elso","sequence":"additional","affiliation":[{"name":"Genetics and Bioinformatics Division and Department of Infection and Immunity, The Walter and Eliza Hall Institute, 1G Royal Parade, Parkville, Victoria 3050, Australia; Department of Medical Biology, University of Melbourne, Parkville, Victoria 3010, Australia; and Menzies Research Institute, 17 Liverpool Street, Hobart, Tasmania 7000, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ken","family":"Simpson","sequence":"additional","affiliation":[{"name":"Genetics and Bioinformatics Division and Department of Infection and Immunity, The Walter and Eliza Hall Institute, 1G Royal Parade, Parkville, Victoria 3050, Australia; Department of Medical Biology, University of Melbourne, Parkville, Victoria 3010, Australia; and Menzies Research Institute, 17 Liverpool Street, Hobart, Tasmania 7000, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joan M.","family":"Curtis","sequence":"additional","affiliation":[{"name":"Genetics and Bioinformatics Division and Department of Infection and Immunity, The Walter and Eliza Hall Institute, 1G Royal Parade, Parkville, Victoria 3050, Australia; Department of Medical Biology, University of Melbourne, Parkville, Victoria 3010, Australia; and Menzies Research Institute, 17 Liverpool Street, Hobart, Tasmania 7000, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beena","family":"Kumar","sequence":"additional","affiliation":[{"name":"Genetics and Bioinformatics Division and Department of Infection and Immunity, The Walter and Eliza Hall Institute, 1G Royal Parade, Parkville, Victoria 3050, Australia; Department of Medical Biology, University of Melbourne, Parkville, Victoria 3010, Australia; and Menzies Research Institute, 17 Liverpool Street, Hobart, Tasmania 7000, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Terence P.","family":"Speed","sequence":"additional","affiliation":[{"name":"Genetics and Bioinformatics Division and Department of Infection and Immunity, The Walter and Eliza Hall Institute, 1G Royal Parade, Parkville, Victoria 3050, Australia; Department of Medical Biology, University of Melbourne, Parkville, Victoria 3010, Australia; and Menzies Research Institute, 17 Liverpool Street, Hobart, Tasmania 7000, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emanuela","family":"Handman","sequence":"additional","affiliation":[{"name":"Genetics and Bioinformatics Division and Department of Infection and Immunity, The Walter and Eliza Hall Institute, 1G Royal Parade, Parkville, Victoria 3050, Australia; Department of Medical Biology, University of Melbourne, Parkville, Victoria 3010, Australia; and Menzies Research Institute, 17 Liverpool Street, Hobart, Tasmania 7000, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simon J.","family":"Foote","sequence":"additional","affiliation":[{"name":"Genetics and Bioinformatics Division and Department of Infection and Immunity, The Walter and Eliza Hall Institute, 1G Royal Parade, Parkville, Victoria 3050, Australia; Department of Medical Biology, University of Melbourne, Parkville, Victoria 3010, Australia; and Menzies Research Institute, 17 Liverpool Street, Hobart, Tasmania 7000, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[2005,10,13]]},"reference":[{"key":"e_1_3_2_1_2","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(85)90459-7"},{"key":"e_1_3_2_2_2","first-page":"61","volume":"86","year":"1991","unstructured":"Andrade, Z. 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