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However, progressive growth of lymphoid tumors was invariably recorded when irradiated angiogenic cells from Kaposi\u2019s sarcoma (KS-IMM) were locally coinjected with MOLT-3 cells or administered later. The persistence of KS-IMM cells\n                    <jats:italic>in vivo<\/jats:italic>\n                    was tracked by flow cytometry and real-time PCR analysis, and it was limited to a few days, during which angiogenesis was induced and preceded tumor growth. The engraftment of other types of poorly tumorigenic cancer cells was also greatly improved by irradiated KS-IMM cells. Moreover, short-term treatment with angiogenic factors, including basic FGF or VEGF, either given as recombinant factors or delivered by retroviral vectors, also accelerated tumor growth. These findings may emphasize that tumor angiogenesis is a process requiring a higher amount of angiogenic factors for its induction than maintenance.\n                  <\/jats:p>","DOI":"10.1073\/pnas.0506200103","type":"journal-article","created":{"date-parts":[[2006,3,6]],"date-time":"2006-03-06T20:34:02Z","timestamp":1141677242000},"page":"4216-4221","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":103,"title":["Interruption of tumor dormancy by a transient angiogenic burst within the tumor microenvironment"],"prefix":"10.1073","volume":"103","author":[{"given":"Stefano","family":"Indraccolo","sequence":"first","affiliation":[{"name":"*Department of Oncology and Surgical Sciences, University of Padova, 35128 Padova, Italy; and"},{"name":"Azienda Ospedaliera e Istituto Oncologico Veneto, 35128 Padova, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Stievano","sequence":"additional","affiliation":[{"name":"*Department of Oncology and Surgical Sciences, University of Padova, 35128 Padova, Italy; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sonia","family":"Minuzzo","sequence":"additional","affiliation":[{"name":"*Department of Oncology and Surgical Sciences, University of Padova, 35128 Padova, Italy; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valeria","family":"Tosello","sequence":"additional","affiliation":[{"name":"*Department of Oncology and Surgical Sciences, University of Padova, 35128 Padova, Italy; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanni","family":"Esposito","sequence":"additional","affiliation":[{"name":"*Department of Oncology and Surgical Sciences, University of Padova, 35128 Padova, Italy; and"},{"name":"Azienda Ospedaliera e Istituto Oncologico Veneto, 35128 Padova, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erich","family":"Piovan","sequence":"additional","affiliation":[{"name":"*Department of Oncology and Surgical Sciences, University of Padova, 35128 Padova, Italy; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rita","family":"Zamarchi","sequence":"additional","affiliation":[{"name":"*Department of Oncology and Surgical Sciences, University of Padova, 35128 Padova, Italy; and"},{"name":"Azienda Ospedaliera e Istituto Oncologico Veneto, 35128 Padova, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luigi","family":"Chieco-Bianchi","sequence":"additional","affiliation":[{"name":"*Department of Oncology and Surgical Sciences, University of Padova, 35128 Padova, Italy; and"},{"name":"Azienda Ospedaliera e Istituto Oncologico Veneto, 35128 Padova, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alberto","family":"Amadori","sequence":"additional","affiliation":[{"name":"*Department of Oncology and Surgical Sciences, University of Padova, 35128 Padova, Italy; and"},{"name":"Azienda Ospedaliera e Istituto Oncologico Veneto, 35128 Padova, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[2006,3,6]]},"reference":[{"key":"e_1_3_3_1_2","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/86.1.45"},{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/nm0597-505"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1006\/scbi.2001.0382"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-9896(199901)187:1<91::AID-PATH234>3.0.CO;2-J"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.136.2.261"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1038\/nm0295-149"},{"key":"e_1_3_3_7_2","first-page":"4575","volume":"55","author":"Rak J.","year":"1995","unstructured":"J. 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