{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T06:24:28Z","timestamp":1791095068363,"version":"4.1.0"},"reference-count":46,"publisher":"National Academy of Sciences","issue":"1","content-domain":{"domain":["www.pnas.org"],"crossmark-restriction":true},"short-container-title":["Proc. Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2006,1,3]]},"abstract":"<jats:p>That auditory hallucinations are voices heard in the absence of external stimuli implies the existence of endogenous neural activity within the auditory cortex responsible for their perception. Further, auditory hallucinations occur across a range of healthy and disease states that include reduced arousal, hypnosis, drug intoxication, delirium, and psychosis. This suggests that, even in health, the auditory cortex has a propensity to spontaneously \u201cactivate\u201d during silence. Here we report the findings of a functional MRI study, designed to examine baseline activity in speech-sensitive auditory regions. During silence, we show that functionally defined speech-sensitive auditory cortex is characterized by intermittent episodes of significantly increased activity in a large proportion (in some cases &gt;30%) of its volume. Bilateral increases in activity are associated with foci of spontaneous activation in the left primary and association auditory cortices and anterior cingulate cortex. We suggest that, within auditory regions, endogenous activity is modulated by anterior cingulate cortex, resulting in spontaneous activation during silence. Hence, an aspect of the brain's \u201cdefault mode\u201d resembles a (preprepared) substrate for the development of auditory hallucinations. These observations may help explain why such hallucinations are ubiquitous.<\/jats:p>","DOI":"10.1073\/pnas.0506268103","type":"journal-article","created":{"date-parts":[[2005,12,21]],"date-time":"2005-12-21T20:34:25Z","timestamp":1135197265000},"page":"189-194","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":105,"title":["Neural activity in speech-sensitive auditory cortex during silence"],"prefix":"10.1073","volume":"103","author":[{"given":"M. D.","family":"Hunter","sequence":"first","affiliation":[{"name":"Sheffield Cognition and Neuroimaging Laboratory (SCANLab), Academic Clinical Psychiatry, Division of Genomic Medicine, and Academic Unit of Radiology, University of Sheffield, The Longley Centre, Norwood Grange Drive, Sheffield S5 7JT, United Kingdom; and Institute for Medicine, Research Center Juelich, 52425 Juelich, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S. B.","family":"Eickhoff","sequence":"additional","affiliation":[{"name":"Sheffield Cognition and Neuroimaging Laboratory (SCANLab), Academic Clinical Psychiatry, Division of Genomic Medicine, and Academic Unit of Radiology, University of Sheffield, The Longley Centre, Norwood Grange Drive, Sheffield S5 7JT, United Kingdom; and Institute for Medicine, Research Center Juelich, 52425 Juelich, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T. W. R.","family":"Miller","sequence":"additional","affiliation":[{"name":"Sheffield Cognition and Neuroimaging Laboratory (SCANLab), Academic Clinical Psychiatry, Division of Genomic Medicine, and Academic Unit of Radiology, University of Sheffield, The Longley Centre, Norwood Grange Drive, Sheffield S5 7JT, United Kingdom; and Institute for Medicine, Research Center Juelich, 52425 Juelich, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T. F. D.","family":"Farrow","sequence":"additional","affiliation":[{"name":"Sheffield Cognition and Neuroimaging Laboratory (SCANLab), Academic Clinical Psychiatry, Division of Genomic Medicine, and Academic Unit of Radiology, University of Sheffield, The Longley Centre, Norwood Grange Drive, Sheffield S5 7JT, United Kingdom; and Institute for Medicine, Research Center Juelich, 52425 Juelich, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I. D.","family":"Wilkinson","sequence":"additional","affiliation":[{"name":"Sheffield Cognition and Neuroimaging Laboratory (SCANLab), Academic Clinical Psychiatry, Division of Genomic Medicine, and Academic Unit of Radiology, University of Sheffield, The Longley Centre, Norwood Grange Drive, Sheffield S5 7JT, United Kingdom; and Institute for Medicine, Research Center Juelich, 52425 Juelich, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P. W. 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