{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T19:04:42Z","timestamp":1791227082800,"version":"4.1.0"},"reference-count":25,"publisher":"National Academy of Sciences","issue":"5","content-domain":{"domain":["www.pnas.org"],"crossmark-restriction":true},"short-container-title":["Proc. Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2006,1,31]]},"abstract":"<jats:p>\n                    During vulval development in\n                    <jats:italic>Caenorhabditis elegans<\/jats:italic>\n                    , six precursor cells acquire a spatial pattern of distinct cell fates. This process is guided by a gradient in the soluble factor, LIN-3, and by direct interactions between neighboring cells mediated by the Notch-like receptor, LIN-12. Genetic evidence has revealed that these two extracellular signals are coupled: lateral cell-cell interactions inhibit LIN-3-mediated signaling, whereas LIN-3 regulates the extent of lateral signaling. To elucidate the quantitative implications of this coupled network topology for cell patterning during vulval development, we developed a mathematical model of LIN-3\/LIN-12-mediated signaling in the vulval precursor cell array. Our analysis reveals that coupling LIN-3 and LIN-12 amplifies cellular perception of the LIN-3 gradient and polarizes lateral signaling, both of which enhance fate segregation beyond that achievable by an uncoupled system.\n                  <\/jats:p>","DOI":"10.1073\/pnas.0506476103","type":"journal-article","created":{"date-parts":[[2006,1,23]],"date-time":"2006-01-23T20:53:41Z","timestamp":1138049621000},"page":"1331-1336","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":50,"title":["Intercellular coupling amplifies fate segregation during\n                    <i>Caenorhabditis elegans<\/i>\n                    vulval development"],"prefix":"10.1073","volume":"103","author":[{"given":"Claudiu A.","family":"Giurumescu","sequence":"first","affiliation":[{"name":"Division of Chemistry and Chemical Engineering and Division of Biology, California Institute of Technology, Pasadena, CA 91125"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul W.","family":"Sternberg","sequence":"additional","affiliation":[{"name":"Division of Chemistry and Chemical Engineering and Division of Biology, California Institute of Technology, Pasadena, CA 91125"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anand R.","family":"Asthagiri","sequence":"additional","affiliation":[{"name":"Division of Chemistry and Chemical Engineering and Division of Biology, California Institute of Technology, Pasadena, CA 91125"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[2006,1,23]]},"reference":[{"key":"e_1_3_2_1_2","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(86)90842-1"},{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1091639"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/35101500"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(95)90317-8"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(83)90377-X"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1038\/335551a0"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2004.03.052"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-4827(02)00097-6"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature01234"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1534-5807(04)00021-8"},{"key":"e_1_3_2_11_2","first-page":"5081","volume":"132","year":"2005","unstructured":"Shaye, D. 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