{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T02:39:20Z","timestamp":1792204760366,"version":"4.4.0"},"reference-count":30,"publisher":"National Academy of Sciences","issue":"37","content-domain":{"domain":["www.pnas.org"],"crossmark-restriction":true},"short-container-title":["Proc. Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2005,9,13]]},"abstract":"<jats:p>\n                    Treatment with synthetic oligodeoxynucleotides containing CpG motifs (CpG ODNs) is remarkably protective against otherwise lethal infection. Here, we describe an essential role for the transcription factor T-bet in mediating the protective function of CpG ODNs. Loss of T-bet in conventional CD11c\n                    <jats:sup>hi<\/jats:sup>\n                    dendritic cells (DCs) and in plasmacytoid DCs impaired production of IFNs. Strikingly, in contrast to\n                    <jats:italic>Rag2<\/jats:italic>\n                    <jats:sup>-\/-<\/jats:sup>\n                    mice,\n                    <jats:italic>Rag2<\/jats:italic>\n                    <jats:sup>-\/-<\/jats:sup>\n                    mice that also lacked T-bet (DKO) could not be rescued from lethal\n                    <jats:italic>Listeria monocytogenes<\/jats:italic>\n                    infection by prior treatment with CpG ODN. Rescue was achieved by adoptive transfer of CD11c\n                    <jats:sup>hi<\/jats:sup>\n                    DCs from WT, but not\n                    <jats:italic>T-bet<\/jats:italic>\n                    <jats:sup>-\/-<\/jats:sup>\n                    , CpG ODN-treated donor mice. We conclude that T-bet in DCs is required for the adjuvant activity of CpG ODN in infection, revealing its vital role in innate immunity.\n                  <\/jats:p>","DOI":"10.1073\/pnas.0506638102","type":"journal-article","created":{"date-parts":[[2005,8,31]],"date-time":"2005-08-31T20:25:16Z","timestamp":1125519916000},"page":"13248-13253","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":44,"title":["The adjuvant activity of CpG DNA requires T-bet expression in dendritic cells"],"prefix":"10.1073","volume":"102","author":[{"given":"Geanncarlo","family":"Lugo-Villarino","sequence":"first","affiliation":[{"name":"Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, MA 02115-6017; Department of Medicine, Harvard Medical School, Boston, MA 02115; and Division of Therapeutic Proteins, Food and Drug Administration, Building 29A, Room 3B19, 8800 Rockville Pike, Bethesda, MD 20892"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shu-Ichi","family":"Ito","sequence":"additional","affiliation":[{"name":"Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, MA 02115-6017; Department of Medicine, Harvard Medical School, Boston, MA 02115; and Division of Therapeutic Proteins, Food and Drug Administration, Building 29A, Room 3B19, 8800 Rockville Pike, Bethesda, MD 20892"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dennis M.","family":"Klinman","sequence":"additional","affiliation":[{"name":"Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, MA 02115-6017; Department of Medicine, Harvard Medical School, Boston, MA 02115; and Division of Therapeutic Proteins, Food and Drug Administration, Building 29A, Room 3B19, 8800 Rockville Pike, Bethesda, MD 20892"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurie H.","family":"Glimcher","sequence":"additional","affiliation":[{"name":"Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, MA 02115-6017; Department of Medicine, Harvard Medical School, Boston, MA 02115; and Division of Therapeutic Proteins, Food and Drug Administration, Building 29A, Room 3B19, 8800 Rockville Pike, Bethesda, MD 20892"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[2005,8,31]]},"reference":[{"key":"e_1_3_2_1_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.immunol.20.100301.064842"},{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0966-842X(01)02039-X"},{"key":"e_1_3_2_3_2","first-page":"166","volume":"6","year":"2004","unstructured":"Ishii, K. 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