{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T20:44:24Z","timestamp":1790196264727,"version":"4.1.0"},"reference-count":29,"publisher":"National Academy of Sciences","issue":"44","content-domain":{"domain":["www.pnas.org"],"crossmark-restriction":true},"short-container-title":["Proc. Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2005,11]]},"abstract":"<jats:p>\n                    We have determined the concentrations of carbonyl sulfide (OCS), dimethylsulfide, and carbon disulfide (CS\n                    <jats:sub>2<\/jats:sub>\n                    ) in the breath of a group of cystic fibrosis (CF) patients and one of healthy controls. At the detection sensitivity in these experiments, room air always contained measurable quantities of these three gases. For each subject the inhaled room concentrations were subtracted from the time-coincident concentrations in exhaled breath air. The most significant differences between the CF and control cohorts in these breath-minus-room values were found for OCS. The control group demonstrated a net uptake of 250 \u00b1 20 parts-per-trillion-by-volume (pptv), whereas the CF cohort had a net uptake of 110 \u00b1 60 pptv (\n                    <jats:italic>P<\/jats:italic>\n                    = 0.00003). Three CF patients exhaled more OCS than they inhaled from the room. The OCS concentrations in the CF cohort were strongly correlated with pulmonary function. The dimethylsulfide concentrations in breath were greatly enhanced over ambient, but no significant difference was observed between the CF and healthy control groups. The net (breath minus room) CS\n                    <jats:sub>2<\/jats:sub>\n                    concentrations for individuals ranged between +180 and -100 pptv. They were slightly greater in the CF cohort (+26 \u00b1 38 pptv) vs. the control group (-17 \u00b1 15 pptv;\n                    <jats:italic>P<\/jats:italic>\n                    = 0.04). Lung disease in CF is accompanied by the subsistence of chronic bacterial infections. Sulfides are known to be produced by bacteria in various systems and were therefore the special target for this investigation. Our results suggest that breath sulfide content deserves attention as a noninvasive marker of respiratory colonization.\n                  <\/jats:p>","DOI":"10.1073\/pnas.0507263102","type":"journal-article","created":{"date-parts":[[2005,10,26]],"date-time":"2005-10-26T04:43:54Z","timestamp":1130301834000},"page":"15762-15767","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":60,"title":["Breath sulfides and pulmonary function in cystic fibrosis"],"prefix":"10.1073","volume":"102","author":[{"given":"M. A.","family":"Kamboures","sequence":"first","affiliation":[{"name":"Departments of Chemistry and Pediatrics, General Clinical Research Center, and Center for Statistical Consulting, University of California, Irvine, CA 92697; Department of Pediatrics, University Hospital Rheinisch-Westf\u00e4lische Technische Hochschule, 52074 Aachen, Germany; and Division of Pediatric Pulmonology, Miller Children's Hospital at Long Beach Memorial Medical Center, Long Beach, CA 90806"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D. R.","family":"Blake","sequence":"additional","affiliation":[{"name":"Departments of Chemistry and Pediatrics, General Clinical Research Center, and Center for Statistical Consulting, University of California, Irvine, CA 92697; Department of Pediatrics, University Hospital Rheinisch-Westf\u00e4lische Technische Hochschule, 52074 Aachen, Germany; and Division of Pediatric Pulmonology, Miller Children's Hospital at Long Beach Memorial Medical Center, Long Beach, CA 90806"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D. M.","family":"Cooper","sequence":"additional","affiliation":[{"name":"Departments of Chemistry and Pediatrics, General Clinical Research Center, and Center for Statistical Consulting, University of California, Irvine, CA 92697; Department of Pediatrics, University Hospital Rheinisch-Westf\u00e4lische Technische Hochschule, 52074 Aachen, Germany; and Division of Pediatric Pulmonology, Miller Children's Hospital at Long Beach Memorial Medical Center, Long Beach, CA 90806"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R. L.","family":"Newcomb","sequence":"additional","affiliation":[{"name":"Departments of Chemistry and Pediatrics, General Clinical Research Center, and Center for Statistical Consulting, University of California, Irvine, CA 92697; Department of Pediatrics, University Hospital Rheinisch-Westf\u00e4lische Technische Hochschule, 52074 Aachen, Germany; and Division of Pediatric Pulmonology, Miller Children's Hospital at Long Beach Memorial Medical Center, Long Beach, CA 90806"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Barker","sequence":"additional","affiliation":[{"name":"Departments of Chemistry and Pediatrics, General Clinical Research Center, and Center for Statistical Consulting, University of California, Irvine, CA 92697; Department of Pediatrics, University Hospital Rheinisch-Westf\u00e4lische Technische Hochschule, 52074 Aachen, Germany; and Division of Pediatric Pulmonology, Miller Children's Hospital at Long Beach Memorial Medical Center, Long Beach, CA 90806"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. K.","family":"Larson","sequence":"additional","affiliation":[{"name":"Departments of Chemistry and Pediatrics, General Clinical Research Center, and Center for Statistical Consulting, University of California, Irvine, CA 92697; Department of Pediatrics, University Hospital Rheinisch-Westf\u00e4lische Technische Hochschule, 52074 Aachen, Germany; and Division of Pediatric Pulmonology, Miller Children's Hospital at Long Beach Memorial Medical Center, Long Beach, CA 90806"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Meinardi","sequence":"additional","affiliation":[{"name":"Departments of Chemistry and Pediatrics, General Clinical Research Center, and Center for Statistical Consulting, University of California, Irvine, CA 92697; Department of Pediatrics, University Hospital Rheinisch-Westf\u00e4lische Technische Hochschule, 52074 Aachen, Germany; and Division of Pediatric Pulmonology, Miller Children's Hospital at Long Beach Memorial Medical Center, Long Beach, CA 90806"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Nussbaum","sequence":"additional","affiliation":[{"name":"Departments of Chemistry and Pediatrics, General Clinical Research Center, and Center for Statistical Consulting, University of California, Irvine, CA 92697; Department of Pediatrics, University Hospital Rheinisch-Westf\u00e4lische Technische Hochschule, 52074 Aachen, Germany; and Division of Pediatric Pulmonology, Miller Children's Hospital at Long Beach Memorial Medical Center, Long Beach, CA 90806"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F. 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