{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T20:44:37Z","timestamp":1792788277167,"version":"4.5.0"},"reference-count":28,"publisher":"National Academy of Sciences","issue":"42","content-domain":{"domain":["www.pnas.org"],"crossmark-restriction":true},"short-container-title":["Proc. Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2005,10,18]]},"abstract":"<jats:p>\n                    Myocardin and the myocardin-related transcription factors (MRTFs) A and B act as coactivators for serum response factor, which plays a key role in cardiovascular development. To determine the functions of MRTF-B\n                    <jats:italic>in vivo<\/jats:italic>\n                    , we generated\n                    <jats:italic>MRTF-B<\/jats:italic>\n                    mutant mice by targeted inactivation of the\n                    <jats:italic>MRTF-B<\/jats:italic>\n                    gene. We show that mice homozygous for an\n                    <jats:italic>MRTF-B<\/jats:italic>\n                    loss-of-function mutation die during mid-gestation from a spectrum of cardiovascular defects that includes abnormal patterning of the branchial arch arteries, double-outlet right ventricle, ventricular septal defects, and thin-walled myocardium. These abnormalities are accompanied by a failure in differentiation of smooth muscle cells within the branchial arch arteries, which are derived from the neural crest. The phenotype of\n                    <jats:italic>MRTF-B<\/jats:italic>\n                    mutant mice is distinct from that of mice lacking myocardin, revealing unique roles for these serum response factor coactivators in the development of different subsets of smooth muscle cells\n                    <jats:italic>in vivo<\/jats:italic>\n                    .\n                  <\/jats:p>","DOI":"10.1073\/pnas.0507346102","type":"journal-article","created":{"date-parts":[[2005,10,4]],"date-time":"2005-10-04T23:18:55Z","timestamp":1128467935000},"page":"15122-15127","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":146,"title":["Requirement of myocardin-related transcription factor-B for remodeling of branchial arch arteries and smooth muscle differentiation"],"prefix":"10.1073","volume":"102","author":[{"given":"Jiyeon","family":"Oh","sequence":"first","affiliation":[{"name":"Department of Molecular Biology and Pathology, University of Texas Southwestern Medical Center, Dallas, TX 75390-9148"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James A.","family":"Richardson","sequence":"additional","affiliation":[{"name":"Department of Molecular Biology and Pathology, University of Texas Southwestern Medical Center, Dallas, TX 75390-9148"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric N.","family":"Olson","sequence":"additional","affiliation":[{"name":"Department of Molecular Biology and Pathology, University of Texas Southwestern Medical Center, Dallas, TX 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