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Although MeCP2 was identified as a methylation-dependent transcriptional repressor, transcriptional profiling of RNAs from mice lacking MeCP2 did not reveal significant gene expression changes, suggesting that MeCP2 does not simply function as a global repressor. Changes in expression of a few genes have been observed, but these alterations do not explain the full spectrum of Rett-like phenotypes, raising the possibility that additional MeCP2 functions play a role in pathogenesis. In this study, we show that MeCP2 interacts with the RNA-binding protein Y box-binding protein 1 and regulates splicing of reporter minigenes. Importantly, we found aberrant alternative splicing patterns in a mouse model of RTT. Thus, we uncovered a previously uncharacterized function of MeCP2 that involves regulation of splicing, in addition to its role as a transcriptional repressor.\n                  <\/jats:p>","DOI":"10.1073\/pnas.0507856102","type":"journal-article","created":{"date-parts":[[2005,10,26]],"date-time":"2005-10-26T20:34:03Z","timestamp":1130358843000},"page":"17551-17558","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":436,"title":["Regulation of RNA splicing by the methylation-dependent transcriptional repressor methyl-CpG binding protein 2"],"prefix":"10.1073","volume":"102","author":[{"given":"Juan I.","family":"Young","sequence":"first","affiliation":[{"name":"Departments of Molecular and Human Genetics, Neurology, Neuroscience, and Pediatrics, Verna and Marrs McLean Department of Biochemistry and Molecular Biology, Programs in Cellular and Molecular Biology and Developmental Biology, and Howard Hughes Medical Institute, Baylor College of Medicine, Houston, TX 77030; 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