{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T14:01:27Z","timestamp":1791295287616,"version":"4.1.0"},"reference-count":49,"publisher":"National Academy of Sciences","issue":"10","content-domain":{"domain":["www.pnas.org"],"crossmark-restriction":true},"short-container-title":["Proc. Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2006,3,7]]},"abstract":"<jats:p>\n                    The Maf-family transcription factor Nrl is a key regulator of photoreceptor differentiation in mammals. Ablation of the\n                    <jats:italic>Nrl<\/jats:italic>\n                    gene in mice leads to functional cones at the expense of rods. We show that a 2.5-kb\n                    <jats:italic>Nrl<\/jats:italic>\n                    promoter segment directs the expression of enhanced GFP specifically to rod photoreceptors and the pineal gland of transgenic mice. GFP is detected shortly after terminal cell division, corresponding to the timing of rod genesis revealed by birthdating studies. In\n                    <jats:italic>\n                      Nrl\n                      <jats:sup>\u2212\/\u2212<\/jats:sup>\n                    <\/jats:italic>\n                    retinas, the GFP+ photoreceptors express S-opsin, consistent with the transformation of rod precursors into cones. We report the gene profiles of freshly isolated flow-sorted GFP+ photoreceptors from wild-type and\n                    <jats:italic>\n                      Nrl\n                      <jats:sup>\u2212\/\u2212<\/jats:sup>\n                    <\/jats:italic>\n                    retinas at five distinct developmental stages. Our results provide a framework for establishing gene regulatory networks that lead to mature functional photoreceptors from postmitotic precursors. Differentially expressed rod and cone genes are excellent candidates for retinopathies.\n                  <\/jats:p>","DOI":"10.1073\/pnas.0508214103","type":"journal-article","created":{"date-parts":[[2006,2,27]],"date-time":"2006-02-27T20:34:16Z","timestamp":1141072456000},"page":"3890-3895","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":282,"title":["Targeting of GFP to newborn rods by Nrl promoter and temporal expression profiling of flow-sorted photoreceptors"],"prefix":"10.1073","volume":"103","author":[{"given":"Masayuki","family":"Akimoto","sequence":"first","affiliation":[{"name":"Departments of *Ophthalmology and Visual Sciences,"},{"name":"Translational Research Center, Kyoto University Hospital, Kyoto 606-8507, Japan; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong","family":"Cheng","sequence":"additional","affiliation":[{"name":"Neuroscience and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dongxiao","family":"Zhu","sequence":"additional","affiliation":[{"name":"Statistics,"},{"name":"Bioinformatics, University of Michigan, Ann Arbor, MI 48105;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph A.","family":"Brzezinski","sequence":"additional","affiliation":[{"name":"Human Genetics,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ritu","family":"Khanna","sequence":"additional","affiliation":[{"name":"Departments of *Ophthalmology and Visual Sciences,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena","family":"Filippova","sequence":"additional","affiliation":[{"name":"Departments of *Ophthalmology and Visual Sciences,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edwin C. T.","family":"Oh","sequence":"additional","affiliation":[{"name":"Neuroscience and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuezhou","family":"Jing","sequence":"additional","affiliation":[{"name":"Statistics,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jose-Luis","family":"Linares","sequence":"additional","affiliation":[{"name":"Departments of *Ophthalmology and Visual Sciences,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew","family":"Brooks","sequence":"additional","affiliation":[{"name":"Departments of *Ophthalmology and Visual Sciences,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sepideh","family":"Zareparsi","sequence":"additional","affiliation":[{"name":"Departments of *Ophthalmology and Visual Sciences,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alan J.","family":"Mears","sequence":"additional","affiliation":[{"name":"Departments of *Ophthalmology and Visual Sciences,"},{"name":"**University of Ottawa Eye Institute and Ottawa Health Research Institute, Ottawa, ON, Canada K1H 8L6"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alfred","family":"Hero","sequence":"additional","affiliation":[{"name":"Statistics,"},{"name":"Electrical Engineering and Computer Science,"},{"name":"Biomedical Engineering, and"},{"name":"Bioinformatics, University of Michigan, Ann Arbor, MI 48105;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tom","family":"Glaser","sequence":"additional","affiliation":[{"name":"Human Genetics,"},{"name":"Internal Medicine, Programs in"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anand","family":"Swaroop","sequence":"additional","affiliation":[{"name":"Departments of *Ophthalmology and Visual Sciences,"},{"name":"Human Genetics,"},{"name":"Translational Research Center, Kyoto University Hospital, Kyoto 606-8507, Japan; and"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[2006,2,27]]},"reference":[{"key":"e_1_3_4_1_2","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1038\/nature01763","volume":"424","author":"Levine M.","year":"2003","unstructured":"M. Levine, R. Tjian Nature 424, 147\u2013151 (2003).","journal-title":"Nature"},{"key":"e_1_3_4_2_2","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1126\/science.1066355","volume":"295","author":"Brivanlou A. H.","year":"2002","unstructured":"A. H. Brivanlou, J. E. Darnell Science 295, 813\u2013818 (2002).","journal-title":"Science"},{"key":"e_1_3_4_3_2","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1042\/bse0370001","volume":"37","author":"Ptashne M.","year":"2001","unstructured":"M. Ptashne, A. Gann Essays Biochem 37, 1\u201315 (2001).","journal-title":"Essays Biochem"},{"key":"e_1_3_4_4_2","doi-asserted-by":"crossref","first-page":"1475","DOI":"10.1073\/pnas.0437746100","volume":"100","author":"Davidson E. H.","year":"2003","unstructured":"E. H. Davidson, D. R. McClay, L. Hood Proc. Natl. Acad. Sci. USA 100, 1475\u20131480 (2003).","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"e_1_3_4_5_2","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1038\/35053522","volume":"2","author":"Livesey F. J.","year":"2001","unstructured":"F. J. Livesey, C. L. Cepko Nat. Rev. Neurosci 2, 109\u2013118 (2001).","journal-title":"Nat. Rev. Neurosci"},{"key":"e_1_3_4_6_2","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1016\/S0896-6273(03)00756-6","volume":"40","author":"Cayouette M.","year":"2003","unstructured":"M. Cayouette, B. A. Barres, M. Raff Neuron 40, 897\u2013904 (2003).","journal-title":"Neuron"},{"key":"e_1_3_4_7_2","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1007\/PL00000686","volume":"57","author":"Levine E. M.","year":"2000","unstructured":"E. M. Levine, S. Fuhrmann, T. A. Reh Cell Mol. Life Sci 57, 224\u2013234 (2000).","journal-title":"Cell Mol. Life Sci"},{"key":"e_1_3_4_8_2","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1002\/cne.901880205","volume":"188","author":"Carter-Dawson L. D.","year":"1979","unstructured":"L. D. Carter-Dawson, M. M. LaVail J. Comp. Neurol 188, 263\u2013272 (1979).","journal-title":"J. Comp. Neurol"},{"key":"e_1_3_4_9_2","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1002\/ar.1092120215","volume":"212","author":"Young R. W.","year":"1985","unstructured":"R. W. Young Anat. Rec 212, 199\u2013205 (1985).","journal-title":"Anat. Rec"},{"key":"e_1_3_4_10_2","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/0165-3806(85)90211-1","volume":"353","author":"Young R. W.","year":"1985","unstructured":"R. W. Young Brain Res 353, 229\u2013239 (1985).","journal-title":"Brain Res"},{"key":"e_1_3_4_11_2","doi-asserted-by":"crossref","first-page":"2497","DOI":"10.1242\/dev.128.13.2497","volume":"128","author":"Brown N. L.","year":"2001","unstructured":"N. L. Brown, S. Patel, J. Brzezinski, T. Glaser Development (Cambridge, U.K.) 128, 2497\u20132508 (2001).","journal-title":"Development (Cambridge, U.K.)"},{"key":"e_1_3_4_12_2","doi-asserted-by":"crossref","first-page":"1313","DOI":"10.1242\/dev.128.8.1313","volume":"128","author":"Hatakeyama J.","year":"2001","unstructured":"J. Hatakeyama, K. Tomita, T. Inoue, R. Kageyama Development (Cambridge, U.K.) 128, 1313\u20131322 (2001).","journal-title":"Development (Cambridge, U.K.)"},{"key":"e_1_3_4_13_2","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1101\/gad.855301","volume":"15","author":"Wang S. W.","year":"2001","unstructured":"S. W. Wang, B. S. Kim, K. Ding, H. Wang, D. Sun, R. L. Johnson, W. H. Klein, L. Gan Genes Dev 15, 24\u201329 (2001).","journal-title":"Genes Dev"},{"key":"e_1_3_4_14_2","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1073\/pnas.93.2.589","volume":"93","author":"Cepko C. L.","year":"1996","unstructured":"C. L. Cepko, C. P. Austin, X. Yang, M. Alexiades, D. Ezzeddine Proc. Natl. Acad. Sci. USA 93, 589\u2013595 (1996).","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"e_1_3_4_15_2","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1021\/bi00272a020","volume":"22","author":"Molday R. S.","year":"1983","unstructured":"R. S. Molday, D. MacKenzie Biochemistry 22, 653\u2013660 (1983).","journal-title":"Biochemistry"},{"key":"e_1_3_4_16_2","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1038\/72887","volume":"24","author":"Cepko C.","year":"2000","unstructured":"C. Cepko Nat. Genet 24, 99\u2013100 (2000).","journal-title":"Nat. Genet"},{"key":"e_1_3_4_17_2","doi-asserted-by":"crossref","first-page":"3738","DOI":"10.1523\/JNEUROSCI.18-10-03738.1998","volume":"18","author":"Morrow E. M.","year":"1998","unstructured":"E. M. Morrow, M. J. Belliveau, C. L. Cepko J. Neurosci 18, 3738\u20133748 (1998).","journal-title":"J. Neurosci"},{"key":"e_1_3_4_18_2","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1073\/pnas.89.1.266","volume":"89","author":"Swaroop A.","year":"1992","unstructured":"A. Swaroop, J. Z. Xu, H. Pawar, A. Jackson, C. Skolnick, N. Agarwal Proc. Natl. Acad. Sci. USA 89, 266\u2013270 (1992).","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"e_1_3_4_19_2","doi-asserted-by":"crossref","first-page":"36824","DOI":"10.1074\/jbc.M105855200","volume":"276","author":"Swain P. K.","year":"2001","unstructured":"P. K. Swain, D. Hicks, A. J. Mears, I. J. Apel, J. E. Smith, S. K. John, A. Hendrickson, A. H. Milam, A. Swaroop J. Biol. Chem 276, 36824\u201336830 (2001).","journal-title":"J. Biol. Chem"},{"key":"e_1_3_4_20_2","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1007\/s00427-005-0476-y","volume":"215","author":"Coolen M.","year":"2005","unstructured":"M. Coolen, K. Sii-Felice, O. Bronchain, A. Mazabraud, F. Bourrat, S. Retaux, M. P. Felder-Schmittbuhl, S. Mazan, J. L. Plouhinec Dev. Genes Evol 215, 327\u2013339 (2005).","journal-title":"Dev. Genes Evol"},{"key":"e_1_3_4_21_2","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1073\/pnas.93.1.191","volume":"93","author":"Rehemtulla A.","year":"1996","unstructured":"A. Rehemtulla, R. Warwar, R. Kumar, X. Ji, D. J. Zack, A. Swaroop Proc. Natl. Acad. Sci. USA 93, 191\u2013195 (1996).","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"e_1_3_4_22_2","doi-asserted-by":"crossref","first-page":"1017","DOI":"10.1016\/S0896-6273(00)80394-3","volume":"19","author":"Chen S.","year":"1997","unstructured":"S. Chen, Q. L. Wang, Z. Nie, H. Sun, G. Lennon, N. G. Copeland, D. J. Gilbert, N. A. Jenkins, D. J. Zack Neuron 19, 1017\u20131030 (1997).","journal-title":"Neuron"},{"key":"e_1_3_4_23_2","doi-asserted-by":"crossref","first-page":"29794","DOI":"10.1074\/jbc.M003658200","volume":"275","author":"Mitton K. P.","year":"2000","unstructured":"K. P. Mitton, P. K. Swain, S. Chen, S. Xu, D. J. Zack, A. Swaroop J. Biol. Chem 275, 29794\u201329799 (2000).","journal-title":"J. Biol. Chem"},{"key":"e_1_3_4_24_2","doi-asserted-by":"crossref","first-page":"34999","DOI":"10.1074\/jbc.M103301200","volume":"276","author":"Lerner L. E.","year":"2001","unstructured":"L. E. Lerner, Y. E. Gribanova, M. Ji, B. E. Knox, D. B. Farber J. Biol. Chem 276, 34999\u201335007 (2001).","journal-title":"J. Biol. Chem"},{"key":"e_1_3_4_25_2","doi-asserted-by":"crossref","first-page":"1563","DOI":"10.1093\/hmg\/ddh173","volume":"13","author":"Cheng H.","year":"2004","unstructured":"H. Cheng, H. Khanna, E. C. Oh, D. Hicks, K. P. Mitton, A. Swaroop Hum. Mol. Genet 13, 1563\u20131575 (2004).","journal-title":"Hum. Mol. Genet"},{"key":"e_1_3_4_26_2","doi-asserted-by":"crossref","first-page":"1487","DOI":"10.1093\/hmg\/ddh160","volume":"13","author":"Yoshida S.","year":"2004","unstructured":"S. Yoshida, A. J. Mears, J. S. Friedman, T. Carter, S. He, E. Oh, Y. Jing, R. Farjo, G. Fleury, C. Barlow, et al. Hum. Mol. Genet 13, 1487\u20131503 (2004).","journal-title":"Hum. Mol. Genet"},{"key":"e_1_3_4_27_2","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1038\/7678","volume":"21","author":"Bessant D. A.","year":"1999","unstructured":"D. A. Bessant, A. M. Payne, K. P. Mitton, Q. L. Wang, P. K. Swain, C. Plant, A. C. Bird, D. J. Zack, A. Swaroop, S. S. Bhattacharya Nat. Genet 21, 355\u2013356 (1999).","journal-title":"Nat. Genet"},{"key":"e_1_3_4_28_2","doi-asserted-by":"crossref","first-page":"17819","DOI":"10.1073\/pnas.0408183101","volume":"101","author":"Nishiguchi K. M.","year":"2004","unstructured":"K. M. Nishiguchi, J. S. Friedman, M. A. Sandberg, A. Swaroop, E. L. Berson, T. P. Dryja Proc. Natl. Acad. Sci. USA 101, 17819\u201317824 (2004).","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"e_1_3_4_29_2","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1038\/ng774","volume":"29","author":"Mears A. J.","year":"2001","unstructured":"A. J. Mears, M. Kondo, P. K. Swain, Y. Takada, R. A. Bush, T. L. Saunders, P. A. Sieving, A. Swaroop Nat. Genet 29, 447\u2013452 (2001).","journal-title":"Nat. Genet"},{"key":"e_1_3_4_30_2","doi-asserted-by":"crossref","first-page":"2156","DOI":"10.1167\/iovs.04-1427","volume":"46","author":"Daniele L. L.","year":"2005","unstructured":"L. L. Daniele, C. Lillo, A. L. Lyubarsky, S. S. Nikonov, N. Philp, A. J. Mears, A. Swaroop, D. S. Williams, E. N. Pugh Invest. Ophthalmol. Visual Sci 46, 2156\u20132167 (2005).","journal-title":"Invest. Ophthalmol. Visual Sci"},{"key":"e_1_3_4_31_2","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1002\/cne.902210103","volume":"221","author":"Blanks J. C.","year":"1983","unstructured":"J. C. Blanks, L. V. Johnson J. Comp. Neurol 221, 31\u201341 (1983).","journal-title":"J. Comp. Neurol"},{"key":"e_1_3_4_32_2","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1167\/iovs.03-0804","volume":"45","author":"Akimoto M.","year":"2004","unstructured":"M. Akimoto, E. Filippova, P. J. Gage, X. Zhu, C. M. Craft, A. Swaroop Invest. Ophthalmol. Visual Sci 45, 42\u201347 (2004).","journal-title":"Invest. Ophthalmol. Visual Sci"},{"key":"e_1_3_4_33_2","first-page":"58","volume":"61","author":"Sinitsina V. F.","year":"1971","unstructured":"V. F. Sinitsina Arkh. Anat. Gistol. Embriol 61, 58\u201367 (1971).","journal-title":"Arkh. Anat. Gistol. Embriol"},{"key":"e_1_3_4_34_2","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1364\/JOSAA.17.000568","volume":"17","author":"Szel A.","year":"2000","unstructured":"A. Szel, A. Lukats, T. Fekete, Z. Szepessy, P. Rohlich J. Opt. Soc. Am. A 17, 568\u2013579 (2000).","journal-title":"J. Opt. Soc. Am. A"},{"key":"e_1_3_4_35_2","doi-asserted-by":"crossref","DOI":"10.1186\/gb-2002-3-8-reviews1022","volume":"3","author":"Swaroop A.","year":"2002","unstructured":"A. Swaroop, D. J. Zack Genome Biol 3, REVIEWS1022. (2002).","journal-title":"Genome Biol"},{"key":"e_1_3_4_36_2","doi-asserted-by":"crossref","first-page":"1797","DOI":"10.1093\/bioinformatics\/bth138","volume":"20","author":"Reich M.","year":"2004","unstructured":"M. Reich, K. Ohm, M. Angelo, P. Tamayo, J. P. Mesirov Bioinformatics 20, 1797\u20131798 (2004).","journal-title":"Bioinformatics"},{"key":"e_1_3_4_37_2","doi-asserted-by":"crossref","first-page":"E247","DOI":"10.1371\/journal.pbio.0020247","volume":"2","author":"Blackshaw S.","year":"2004","unstructured":"S. Blackshaw, S. Harpavat, J. Trimarchi, L. Cai, H. Huang, W. P. Kuo, G. Weber, K. Lee, R. E. Fraioli, S. H. Cho, et al. PLoS Biol 2, E247 (2004).","journal-title":"PLoS Biol"},{"key":"e_1_3_4_38_2","doi-asserted-by":"crossref","first-page":"4983","DOI":"10.1093\/nar\/29.24.4983","volume":"29","author":"Mu X.","year":"2001","unstructured":"X. Mu, S. Zhao, R. Pershad, T. F. Hsieh, A. Scarpa, S. W. Wang, R. A. White, P. D. Beremand, T. L. Thomas, L. Gan, et al. Nucleic Acids Res 29, 4983\u20134993 (2001).","journal-title":"Nucleic Acids Res"},{"key":"e_1_3_4_39_2","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.1167\/iovs.03-0806","volume":"45","author":"Dorrell M. I.","year":"2004","unstructured":"M. I. Dorrell, E. Aguilar, C. Weber, M. Friedlander Invest. Ophthalmol. Visual Sci 45, 1009\u20131019 (2004).","journal-title":"Invest. Ophthalmol. Visual Sci"},{"key":"e_1_3_4_40_2","doi-asserted-by":"crossref","first-page":"7576","DOI":"10.1523\/JNEUROSCI.2245-04.2004","volume":"24","author":"Strettoi E.","year":"2004","unstructured":"E. Strettoi, A. J. Mears, A. Swaroop J. Neurosci 24, 7576\u20137582 (2004).","journal-title":"J. Neurosci"},{"key":"e_1_3_4_41_2","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1038\/83829","volume":"27","author":"Ng L.","year":"2001","unstructured":"L. Ng, J. B. Hurley, B. Dierks, M. Srinivas, C. Salto, B. Vennstrom, T. A. Reh, D. Forrest Nat. Genet 27, 94\u201398 (2001).","journal-title":"Nat. Genet"},{"key":"e_1_3_4_42_2","doi-asserted-by":"crossref","first-page":"5932","DOI":"10.1073\/pnas.89.13.5932","volume":"89","author":"Okano T.","year":"1992","unstructured":"T. Okano, D. Kojima, Y. Fukada, Y. Shichida, T. Yoshizawa Proc. Natl. Acad. Sci. USA 89, 5932\u20135936 (1992).","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"e_1_3_4_43_2","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/S0378-1119(01)00643-6","volume":"276","author":"Yokoyama S.","year":"2001","unstructured":"S. Yokoyama, N. S. Blow Gene 276, 117\u2013125 (2001).","journal-title":"Gene"},{"key":"e_1_3_4_44_2","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1126\/science.1099955","volume":"306","author":"Arendt D.","year":"2004","unstructured":"D. Arendt, K. Tessmar-Raible, H. Snyman, A. W. Dorresteijn, J. Wittbrodt Science 306, 869\u2013871 (2004).","journal-title":"Science"},{"key":"e_1_3_4_45_2","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1093\/bioinformatics\/btg405","volume":"20","author":"Gautier L.","year":"2004","unstructured":"L. Gautier, L. Cope, B. M. Bolstad, R. A. Irizarry Bioinformatics 20, 307\u2013315 (2004).","journal-title":"Bioinformatics"},{"key":"e_1_3_4_46_2","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1093\/biostatistics\/4.2.249","volume":"4","author":"Irizarry R. A.","year":"2003","unstructured":"R. A. Irizarry, B. Hobbs, F. Collin, Y. D. Beazer-Barclay, K. J. Antonellis, U. Scherf, T. P. Speed Biostatistics 4, 249\u2013264 (2003).","journal-title":"Biostatistics"},{"key":"e_1_3_4_47_2","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1198\/016214504000001907","volume":"100","author":"Benjamini Y.","year":"2005","unstructured":"Y. Benjamini, D. Yekutieli J. Am. Stat. Assoc 100, 71\u201380 (2005).","journal-title":"J. Am. Stat. Assoc"},{"key":"e_1_3_4_48_2","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1038\/ng1201-365","volume":"29","author":"Brazma A.","year":"2001","unstructured":"A. Brazma, P. Hingamp, J. Quackenbush, G. Sherlock, P. Spellman, C. Stoeckert, J. Aach, W. Ansorge, C. A. Ball, H. C. Causton, et al. Nat. Genet 29, 365\u2013371 (2001).","journal-title":"Nat. Genet"},{"key":"e_1_3_4_49_2","doi-asserted-by":"crossref","first-page":"14863","DOI":"10.1073\/pnas.95.25.14863","volume":"95","author":"Eisen M. B.","year":"1998","unstructured":"M. B. Eisen, P. T. Spellman, P. O. Brown, D. Botstein Proc. Natl. Acad. Sci. USA 95, 14863\u201314868 (1998).","journal-title":"Proc. Natl. Acad. Sci. USA"}],"container-title":["Proceedings of the National Academy of Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pnas.org\/doi\/pdf\/10.1073\/pnas.0508214103","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,6,7]],"date-time":"2022-06-07T02:13:31Z","timestamp":1654568011000},"score":1,"resource":{"primary":{"URL":"https:\/\/pnas.org\/doi\/full\/10.1073\/pnas.0508214103"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,2,27]]},"references-count":49,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2006,3,7]]}},"alternative-id":["10.1073\/pnas.0508214103"],"URL":"https:\/\/doi.org\/10.1073\/pnas.0508214103","relation":{},"ISSN":["0027-8424","1091-6490"],"issn-type":[{"value":"0027-8424","type":"print"},{"value":"1091-6490","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,2,27]]},"assertion":[{"value":"2005-09-20","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2006-02-27","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}