{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T04:44:34Z","timestamp":1791348274882,"version":"4.3.1"},"reference-count":36,"publisher":"National Academy of Sciences","issue":"47","content-domain":{"domain":["www.pnas.org"],"crossmark-restriction":true},"short-container-title":["Proc. Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2005,11,22]]},"abstract":"<jats:p>\n                    DYX2 on 6p22 is the most replicated reading disability (RD) locus. By saturating a previously identified peak of association with single nucleotide polymorphism markers, we identified a large polymorphic deletion that encodes tandem repeats of putative brain-related transcription factor binding sites in intron 2 of\n                    <jats:italic>DCDC2<\/jats:italic>\n                    . Alleles of this compound repeat are in significant disequilibrium with multiple reading traits. RT-PCR data show that\n                    <jats:italic>DCDC2<\/jats:italic>\n                    localizes to the regions of the brain where fluent reading occurs, and RNA interference studies show that down-regulation alters neuronal migration. The statistical and functional studies are complementary and are consistent with the latest clinical imaging data for RD. Thus, we propose that\n                    <jats:italic>DCDC2<\/jats:italic>\n                    is a candidate gene for RD.\n                  <\/jats:p>","DOI":"10.1073\/pnas.0508591102","type":"journal-article","created":{"date-parts":[[2005,11,8]],"date-time":"2005-11-08T22:08:46Z","timestamp":1131487726000},"page":"17053-17058","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":333,"title":["<i>DCDC2<\/i>\n                    is associated with reading disability and modulates neuronal development in the brain"],"prefix":"10.1073","volume":"102","author":[{"given":"Haiying","family":"Meng","sequence":"first","affiliation":[{"name":"Department of Pediatrics, Yale Child Health Research Center, Yale University School of Medicine, New Haven, CT 06520; Munroe Meyer Institute, University of Nebraska Medical Center, Omaha, NE 68198; W. M. Keck Foundation Biotechnology Resource Laboratory, Yale University School of Medicine, New Haven, CT 06511; SoftGenetics, State College, PA 16803; Department of Psychology and Institute for Behavioral Genetics, University of Colorado, Boulder, CO 80309; Department of Psychology, University of Denver..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shelley D.","family":"Smith","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Yale Child Health Research Center, Yale University School of Medicine, New Haven, CT 06520; Munroe Meyer Institute, University of Nebraska Medical Center, Omaha, NE 68198; W. M. 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