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The NT embryos' gene expression profiles were drastically different from those of their donor cells and closely resembled those of the naturally fertilized embryos. Our findings demonstrate that the NT embryos have undergone significant nuclear reprogramming by the blastocyst stage; however, problems may occur during redifferentiation for tissue genesis and organogenesis, and small reprogramming errors may be magnified downstream in development.<\/jats:p>","DOI":"10.1073\/pnas.0508952102","type":"journal-article","created":{"date-parts":[[2005,11,28]],"date-time":"2005-11-28T20:34:10Z","timestamp":1133210050000},"page":"17582-17587","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":161,"title":["Global gene expression profiles reveal significant nuclear reprogramming by the blastocyst stage after cloning"],"prefix":"10.1073","volume":"102","author":[{"given":"Sadie L.","family":"Smith","sequence":"first","affiliation":[{"name":"Center for Regenerative Biology\/Department of Animal Science, University of Connecticut, Storrs, CT 06269; Department of Animal Sciences, University of Illinois at Urbana\u2013Champaign, Urbana, IL 61801; and Unit\u00e9 Mixte de Recherche Biologie du D\u00e9veloppement et Reproduction, Institut National de la Recherche Agronomique, 78352 Jouy-en-Josas, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robin E.","family":"Everts","sequence":"additional","affiliation":[{"name":"Center for Regenerative Biology\/Department of Animal Science, University of Connecticut, Storrs, CT 06269; Department of Animal Sciences, University of Illinois at Urbana\u2013Champaign, Urbana, IL 61801; and Unit\u00e9 Mixte de Recherche Biologie du D\u00e9veloppement et Reproduction, Institut National de la Recherche Agronomique, 78352 Jouy-en-Josas, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"X. 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