{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T05:36:26Z","timestamp":1791178586079,"version":"4.1.0"},"reference-count":45,"publisher":"National Academy of Sciences","issue":"6","content-domain":{"domain":["www.pnas.org"],"crossmark-restriction":true},"short-container-title":["Proc. Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2006,2,7]]},"abstract":"<jats:p>\n                    Infections caused by the obligate intracellular pathogen\n                    <jats:italic>Chlamydia trachomatis<\/jats:italic>\n                    have a marked impact on human health.\n                    <jats:italic>C. trachomatis<\/jats:italic>\n                    serovariants are the leading cause of bacterial sexually transmitted disease and infectious preventable blindness. Despite decades of effort, there is no practical vaccine against\n                    <jats:italic>C. trachomatis<\/jats:italic>\n                    diseases. Here we report that all\n                    <jats:italic>C. trachomatis<\/jats:italic>\n                    reference serotypes responsible for sexually transmitted disease and blinding trachoma synthesize a highly conserved surface-exposed antigen termed polymorphic membrane protein D (PmpD). We show that Ab specific to PmpD are neutralizing\n                    <jats:italic>in vitro<\/jats:italic>\n                    . We also present evidence that Ab against serovariable-neutralizing targets, such as the major outer membrane protein, block PmpD neutralization. This finding suggests that a decoy-like immune evasion strategy may be active\n                    <jats:italic>in vivo<\/jats:italic>\n                    whereby immunodominant type-specific surface antigens block the neutralizing ability of species-common PmpD Ab. Collectively, these results show that PmpD is a previously uncharacterized\n                    <jats:italic>C. trachomatis<\/jats:italic>\n                    species-common pan-neutralizing target. Moreover, a vaccine protocol using recombinant PmpD to elicit neutralizing Ab in the absence of immunodominant type-specific Ab might be highly efficacious and surpass the level of protection achieved through natural immunity.\n                  <\/jats:p>","DOI":"10.1073\/pnas.0508983103","type":"journal-article","created":{"date-parts":[[2006,1,30]],"date-time":"2006-01-30T21:03:29Z","timestamp":1138655009000},"page":"1894-1899","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":134,"title":["<i>Chlamydia trachomatis<\/i>\n                    polymorphic membrane protein D is a species-common pan-neutralizing antigen"],"prefix":"10.1073","volume":"103","author":[{"given":"Deborah D.","family":"Crane","sequence":"first","affiliation":[{"name":"*Laboratory of Intracellular Parasites and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John H.","family":"Carlson","sequence":"additional","affiliation":[{"name":"*Laboratory of Intracellular Parasites and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth R.","family":"Fischer","sequence":"additional","affiliation":[{"name":"Research Technology Branch, Rocky Mountain Laboratory, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT 59840;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrik","family":"Bavoil","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences, School of Dentistry, University of Maryland, Baltimore, MD 21201; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ru-ching","family":"Hsia","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences, School of Dentistry, University of Maryland, Baltimore, MD 21201; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chun","family":"Tan","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences, School of Dentistry, University of Maryland, Baltimore, MD 21201; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cho-chou","family":"Kuo","sequence":"additional","affiliation":[{"name":"Department of Pathobiology, University of Washington, Seattle, WA 98195"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harlan D.","family":"Caldwell","sequence":"additional","affiliation":[{"name":"*Laboratory of Intracellular Parasites and"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[2006,1,30]]},"reference":[{"key":"e_1_3_3_1_2","first-page":"844","volume":"82","author":"Resnikoff S.","year":"2004","unstructured":"S. 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