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The mAb 8AH8AL inhibited the spread of vaccinia virus as well as variola virus (the causative agent of smallpox)\n                    <jats:italic>in vitro<\/jats:italic>\n                    , protected mice from subsequent intranasal challenge with virulent vaccinia virus, protected mice when administered 2 days after challenge, and provided significantly greater protection than that afforded by a previously isolated rat anti-B5 mAb (19C2) or by vaccinia immune globulin. The mAb bound to a conformational epitope between amino acids 20 and 130 of B5. These chimpanzee\/human anti-B5 mAbs may be useful in the prevention and treatment of vaccinia virus-induced complications of vaccination against smallpox and may also be effective in the immunoprophylaxis and immunotherapy of smallpox.\n                  <\/jats:p>","DOI":"10.1073\/pnas.0510598103","type":"journal-article","created":{"date-parts":[[2006,1,25]],"date-time":"2006-01-25T20:48:57Z","timestamp":1138222137000},"page":"1882-1887","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":101,"title":["Chimpanzee\/human mAbs to vaccinia virus B5 protein neutralize vaccinia and smallpox viruses and protect mice against vaccinia virus"],"prefix":"10.1073","volume":"103","author":[{"given":"Zhaochun","family":"Chen","sequence":"first","affiliation":[{"name":"*Hepatitis Viruses Section,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patricia","family":"Earl","sequence":"additional","affiliation":[{"name":"Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey","family":"Americo","sequence":"additional","affiliation":[{"name":"Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Inger","family":"Damon","sequence":"additional","affiliation":[{"name":"Centers for Disease Control and Prevention, Atlanta, GA 30333;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Scott K.","family":"Smith","sequence":"additional","affiliation":[{"name":"Centers for Disease Control and Prevention, Atlanta, GA 30333;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi-Hua","family":"Zhou","sequence":"additional","affiliation":[{"name":"*Hepatitis Viruses Section,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fujuan","family":"Yu","sequence":"additional","affiliation":[{"name":"*Hepatitis Viruses Section,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew","family":"Sebrell","sequence":"additional","affiliation":[{"name":"*Hepatitis Viruses Section,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suzanne","family":"Emerson","sequence":"additional","affiliation":[{"name":"Molecular Hepatitis Section, Laboratory of Infectious Diseases, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gary","family":"Cohen","sequence":"additional","affiliation":[{"name":"Department of Microbiology, School of Dental Medicine, University of Pennsylvania, Philadelphia, PA 19104; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roselyn J.","family":"Eisenberg","sequence":"additional","affiliation":[{"name":"Department of Microbiology, School of Dental Medicine, University of Pennsylvania, Philadelphia, PA 19104; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juraj","family":"Svitel","sequence":"additional","affiliation":[{"name":"**Protein Biophysics Resource, Office of Research Services, Office of the Director, National Institutes of Health, Bethesda, MD 20892;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Schuck","sequence":"additional","affiliation":[{"name":"**Protein Biophysics Resource, Office of Research Services, Office of the Director, National Institutes of Health, Bethesda, MD 20892;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William","family":"Satterfield","sequence":"additional","affiliation":[{"name":"Department of Veterinary Sciences, University of Texas M. 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