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We have, however, identified a compound that promotes inclusion formation in cellular models of both Huntington\u2019s disease and Parkinson\u2019s disease. Of particular interest, this compound prevents huntingtin-mediated proteasome dysfunction and reduces \u03b1-synuclein-mediated toxicity. These results demonstrate that compounds that increase inclusion formation may actually lessen cellular pathology in both Huntington\u2019s and Parkinson\u2019s diseases, suggesting a therapeutic approach for neurodegenerative diseases caused by protein misfolding.<\/jats:p>","DOI":"10.1073\/pnas.0511256103","type":"journal-article","created":{"date-parts":[[2006,3,6]],"date-time":"2006-03-06T20:34:02Z","timestamp":1141677242000},"page":"4246-4251","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":219,"title":["Pharmacological promotion of inclusion formation: A therapeutic approach for Huntington\u2019s and Parkinson\u2019s diseases"],"prefix":"10.1073","volume":"103","author":[{"given":"Ruth A.","family":"Bodner","sequence":"first","affiliation":[{"name":"*Center for Cancer Research, Massachusetts Institute of Technology, Room E18-505, 77 Massachusetts Avenue, Cambridge, MA 02139; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tiago Fleming","family":"Outeiro","sequence":"additional","affiliation":[{"name":"MassGeneral Institute for Neurodegenerative Disease, Massachusetts General Hospital, and Harvard Medical School, Charlestown, MA 02129"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen","family":"Altmann","sequence":"additional","affiliation":[{"name":"MassGeneral Institute for Neurodegenerative Disease, Massachusetts General Hospital, and Harvard Medical School, Charlestown, MA 02129"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michele M.","family":"Maxwell","sequence":"additional","affiliation":[{"name":"MassGeneral Institute for Neurodegenerative Disease, Massachusetts General Hospital, and Harvard Medical School, Charlestown, MA 02129"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephanie H.","family":"Cho","sequence":"additional","affiliation":[{"name":"*Center for Cancer Research, Massachusetts Institute of Technology, Room E18-505, 77 Massachusetts Avenue, Cambridge, MA 02139; 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