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U.S.A."],"published-print":{"date-parts":[[2006,3,7]]},"abstract":"<jats:p>\n                    Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) participates in a cell death cascade wherein a variety of stimuli activate nitric oxide (NO) synthases with NO nitrosylating GAPDH, conferring on it the ability to bind to Siah, an E3-ubiquitin-ligase, whose nuclear localization signal enables the GAPDH\/Siah protein complex to translocate to the nucleus where degradation of Siah targets elicits cell death.\n                    <jats:italic>R<\/jats:italic>\n                    -(\u2212)-Deprenyl (deprenyl) ameliorates the progression of disability in early Parkinson\u2019s disease and also has neuroprotective actions. We show that deprenyl and a related agent, TCH346, in subnanomolar concentrations, prevent\n                    <jats:italic>S<\/jats:italic>\n                    -nitrosylation of GAPDH, the binding of GAPDH to Siah, and nuclear translocation of GAPDH. 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