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The current study shows that immunization with naked DNA by direct injection into a peripheral lymph node enhances immunogenicity by 100- to 1,000-fold, inducing strong and biologically relevant CD8\n                    <jats:sup>+<\/jats:sup>\n                    cytotoxic T lymphocyte responses. Because injection directly into a lymph node is a rapid and easy procedure in humans, these results have important clinical implications for DNA vaccination.\n                  <\/jats:p>","DOI":"10.1073\/pnas.051630798","type":"journal-article","created":{"date-parts":[[2002,7,26]],"date-time":"2002-07-26T10:41:48Z","timestamp":1027680108000},"page":"3299-3303","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":128,"title":["Intralymphatic immunization enhances DNA vaccination"],"prefix":"10.1073","volume":"98","author":[{"given":"Kevin J.","family":"Maloy","sequence":"first","affiliation":[{"name":"Department of Dermatology, and Institute of Experimental Immunology, Universit\u00e4tsspital Z\u00fcrich, Schmelzbergstrasse 12, CH-8091 Zurich, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iris","family":"Erdmann","sequence":"additional","affiliation":[{"name":"Department of Dermatology, and Institute of 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