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We developed a mathematical model of TB\/HIV coepidemics to examine the impact of community-wide implementation of IPT for TB\u2013HIV coinfected individuals on the dynamics of drug-sensitive and -resistant TB epidemics. We found that community-wide IPT will reduce the incidence of TB in the short-term but may also speed the emergence of drug-resistant TB. We conclude that community-wide IPT in areas of emerging HIV and drug-resistant TB should be coupled with diagnostic and treatment policies designed to identify and effectively treat the increasing proportion of patients with drug-resistant TB.\n                  <\/jats:p>","DOI":"10.1073\/pnas.0600349103","type":"journal-article","created":{"date-parts":[[2006,4,21]],"date-time":"2006-04-21T20:37:47Z","timestamp":1145651867000},"page":"7042-7047","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":92,"title":["Beneficial and perverse effects of isoniazid preventive therapy for latent tuberculosis infection in HIV\u2013tuberculosis coinfected populations"],"prefix":"10.1073","volume":"103","author":[{"given":"Ted","family":"Cohen","sequence":"first","affiliation":[{"name":"*Division of Social Medicine and Health Inequalities, Brigham and Women's Hospital, One Brigham Circle, 1620 Tremont Street, Boston, MA 02120;"},{"name":"Department of Epidemiology, Harvard School of Public Health, 677 Huntington Avenue, Boston, MA 02115;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc","family":"Lipsitch","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, Harvard School of Public Health, 677 Huntington Avenue, Boston, MA 02115;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rochelle P.","family":"Walensky","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases and General Medicine, Department of Medicine, Massachusetts General Hospital, 55 Fruit Street, Boston, MA 92114-2622; and"},{"name":"Center for AIDS Research, Harvard Medical School, 50 Staniford Street, Ninth Floor, Boston, MA 02114"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Megan","family":"Murray","sequence":"additional","affiliation":[{"name":"*Division of Social Medicine and Health Inequalities, Brigham and Women's Hospital, One Brigham Circle, 1620 Tremont Street, Boston, MA 02120;"},{"name":"Department of Epidemiology, Harvard School of Public Health, 677 Huntington Avenue, Boston, MA 02115;"},{"name":"Division of Infectious Diseases and General Medicine, Department of Medicine, Massachusetts General Hospital, 55 Fruit Street, Boston, MA 92114-2622; and"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[2006,5,2]]},"reference":[{"key":"e_1_3_3_1_2","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.163.9.1009"},{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.293.22.2767"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/nri1704"},{"key":"e_1_3_3_4_2","first-page":"28","volume":"26","author":"Ferebee S. 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