{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T22:32:35Z","timestamp":1793226755350,"version":"4.5.0"},"reference-count":49,"publisher":"National Academy of Sciences","issue":"36","content-domain":{"domain":["www.pnas.org"],"crossmark-restriction":true},"short-container-title":["Proc. Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2006,9,5]]},"abstract":"<jats:p>\n                    The proboscis is an important head appendage in insects that has primarily been thought to process gustatory information during food intake. Indeed, in\n                    <jats:italic>Drosophila<\/jats:italic>\n                    and other insects in which they have been identified, most gustatory receptors are expressed in proboscis neurons. Our previous characterization of the expression of AgOR7, a highly conserved odorant receptor (OR) of the Afrotropical malaria vector mosquito\n                    <jats:italic>Anopheles gambiae<\/jats:italic>\n                    in the labellum at the tip of the proboscis was suggestive of a potential olfactory function in this mosquito appendage. To test this hypothesis, we used electrophysiological recording and neuronal tracing, and carried out a molecular characterization of candidate OR expression in the labellum of\n                    <jats:italic>A. gambiae<\/jats:italic>\n                    . These studies have uncovered a set of labial olfactory responses to a small spectrum of human-related odorants, such as isovaleric acid, butylamine, and several ketones and oxocarboxylic acids. Molecular analyses indicated that at least 24 conventional OR genes are expressed throughout the proboscis. Furthermore, to more fully examine AgOR expression within this tissue, we characterized the AgOR profile within a single labial olfactory sensillum. This study provides compelling data to support the hypothesis that a cryptic set of olfactory neurons that respond to a small set of odorants are present in the mouth parts of hematophagous mosquitoes. This result is consistent with an important role for the labellum in the close-range discrimination of bloodmeal hosts that directly impacts the ability of\n                    <jats:italic>A. gambiae<\/jats:italic>\n                    to transmit malaria and other diseases.\n                  <\/jats:p>","DOI":"10.1073\/pnas.0601107103","type":"journal-article","created":{"date-parts":[[2006,8,28]],"date-time":"2006-08-28T22:10:40Z","timestamp":1156803040000},"page":"13526-13531","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":136,"title":["Olfactory responses in a gustatory organ of the malaria vector mosquito\n                    <i>Anopheles gambiae<\/i>"],"prefix":"10.1073","volume":"103","author":[{"given":"Hyung-Wook","family":"Kwon","sequence":"first","affiliation":[{"name":"Department of Biological Sciences, Center for Molecular Neuroscience, Institute of Chemical Biology, and Program in Developmental Biology, Vanderbilt 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