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As a result of the congenital abnormality of both outer and middle ears, these mice were hearing impaired.\n                    <jats:italic>In situ<\/jats:italic>\n                    hybridization revealed that PACT mRNA was expressed in specific regions of all three parts of the ear in adult and embryonic wild-type mice. Our study demonstrated an essential role of PACT in mammalian ear development and produced the first animal model for studying human microtia.\n                  <\/jats:p>","DOI":"10.1073\/pnas.0601287103","type":"journal-article","created":{"date-parts":[[2006,3,29]],"date-time":"2006-03-29T20:34:49Z","timestamp":1143664489000},"page":"5823-5828","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":63,"title":["A role of the double-stranded RNA-binding protein PACT in mouse ear development and hearing"],"prefix":"10.1073","volume":"103","author":[{"given":"Theresa M.","family":"Rowe","sequence":"first","affiliation":[{"name":"Departments of *Molecular Genetics and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark","family":"Rizzi","sequence":"additional","affiliation":[{"name":"Departments of *Molecular Genetics and"},{"name":"Neurosciences and"},{"name":"Head and Neck Institute, Cleveland Clinic Foundation, Cleveland, OH 44195"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keiko","family":"Hirose","sequence":"additional","affiliation":[{"name":"Neurosciences and"},{"name":"Head and Neck Institute, Cleveland Clinic Foundation, Cleveland, OH 44195"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregory A.","family":"Peters","sequence":"additional","affiliation":[{"name":"Departments of *Molecular Genetics and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ganes C.","family":"Sen","sequence":"additional","affiliation":[{"name":"Departments of *Molecular Genetics and"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[2006,4,11]]},"reference":[{"key":"e_1_3_3_1_2","doi-asserted-by":"publisher","DOI":"10.1093\/emboj\/17.15.4379"},{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.274.22.15427"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrm1528"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.21.6.1908-1920.2001"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1096\/fj.02-0958rev"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(90)90374-N"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.2011739"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)80376-1"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(91)90138-O"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1097-2765(02)00730-X"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/0012-1606(88)90162-5"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1002\/j.1460-2075.1995.tb00300.x"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.290.5497.1765"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1089\/107999003772084806"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1006\/dbio.2001.0169"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1038\/9684"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.95.23.13709"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1038\/35017558"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1242\/dev.107.Supplement.13"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1093\/emboj\/19.6.1366"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.19-01-00288.1999"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1091\/mbc.10.9.2945"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/29.16.3385"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.1091\/mbc.11.3.999"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2004.11.050"},{"key":"e_1_3_3_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0166-2236(98)01366-6"},{"key":"e_1_3_3_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0094-1298(20)32136-2"},{"key":"e_1_3_3_28_2","first-page":"223","volume":"43","author":"Marszalek B.","year":"2002","unstructured":"B. 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