{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T17:46:27Z","timestamp":1791308787925,"version":"4.3.1"},"reference-count":34,"publisher":"National Academy of Sciences","issue":"19","content-domain":{"domain":["www.pnas.org"],"crossmark-restriction":true},"short-container-title":["Proc. Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2006,5,9]]},"abstract":"<jats:p>\n                    We report an extensive characterization of the Na\n                    <jats:sup>+<\/jats:sup>\n                    \/monocarboxylate transporter (SMCT), a plasma membrane protein that mediates active transport of monocarboxylates such as propionate and nicotinate, and we show that SMCT may play a role in colorectal cancer diagnosis. SMCT, the product of the\n                    <jats:italic>SLC5A8<\/jats:italic>\n                    gene, is 70% similar to the Na\n                    <jats:sup>+<\/jats:sup>\n                    \/I\n                    <jats:sup>\u2212<\/jats:sup>\n                    symporter, the protein that mediates active I\n                    <jats:sup>\u2212<\/jats:sup>\n                    uptake in the basolateral surface of thyrocytes and other cells. SMCT was reported in the apical surface of thyrocytes and formerly proposed also to transport I\n                    <jats:sup>\u2212<\/jats:sup>\n                    and was called the apical I\n                    <jats:sup>\u2212<\/jats:sup>\n                    transporter. However, it is now clear that SMCT does not transport I\n                    <jats:sup>\u2212<\/jats:sup>\n                    . Here we demonstrate a high-affinity Na\n                    <jats:sup>+<\/jats:sup>\n                    -dependent monocarboxylate transport system in thyroid cells, which is likely to be SMCT. We show that, whereas thyroidal Na\n                    <jats:sup>+<\/jats:sup>\n                    \/I\n                    <jats:sup>\u2212<\/jats:sup>\n                    symporter expression is thyroid-stimulating hormone (TSH)-dependent and basolateral, SMCT expression is TSH-independent and apical not only in the thyroid but also in kidney and colon epithelial cells and in polarized Madin\u2013Darby canine kidney cells. We determine the kinetic parameters of SMCT activity and show its inhibition by ibuprofen (\n                    <jats:italic>K<\/jats:italic>\n                    <jats:sub>i<\/jats:sub>\n                    = 73 \u00b1 9 \u03bcM) in\n                    <jats:italic>Xenopus laevis<\/jats:italic>\n                    oocytes. SMCT was proposed to be a tumor suppressor in colon cancer [Li, H.,\n                    <jats:italic>et al.<\/jats:italic>\n                    (2003)\n                    <jats:italic>Proc. Natl. Acad. Sci. USA<\/jats:italic>\n                    100, 8412\u20138417]. Significantly, we show that higher expression of SMCT in colon samples from 113 colorectal cancer patients correlates with longer disease-free survival, suggesting that SMCT expression may be a favorable indicator of colorectal cancer prognosis.\n                  <\/jats:p>","DOI":"10.1073\/pnas.0602365103","type":"journal-article","created":{"date-parts":[[2006,5,2]],"date-time":"2006-05-02T21:30:29Z","timestamp":1146605429000},"page":"7270-7275","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":102,"title":["Na\n                    <sup>+<\/sup>\n                    \/monocarboxylate transport (SMCT) protein expression correlates with survival in colon cancer: Molecular characterization of SMCT"],"prefix":"10.1073","volume":"103","author":[{"given":"Viktoriya","family":"Paroder","sequence":"first","affiliation":[{"name":"*Department of Molecular Pharmacology, Albert Einstein College of Medicine, Bronx, NY 10461;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shelly R.","family":"Spencer","sequence":"additional","affiliation":[{"name":"Biological Sciences Department, California State Polytechnic University, Pomona, CA 91768;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monika","family":"Paroder","sequence":"additional","affiliation":[{"name":"*Department of Molecular Pharmacology, Albert Einstein College of Medicine, Bronx, NY 10461;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diego","family":"Arango","sequence":"additional","affiliation":[{"name":"Molecular Oncology and Aging Group, Molecular Biology and Biochemistry Research Center, Valle Hebron Hospital Research Institute, Passeig Valle d\u2019Hebron 119-129, 08035 Barcelona, Spain; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Jr.","given":"Simo","family":"Schwartz","sequence":"additional","affiliation":[{"name":"Molecular Oncology and Aging Group, Molecular Biology and Biochemistry Research Center, Valle Hebron Hospital Research Institute, Passeig Valle d\u2019Hebron 119-129, 08035 Barcelona, Spain; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John M.","family":"Mariadason","sequence":"additional","affiliation":[{"name":"Department of Oncology, Montefiore Medical Center, Albert Einstein Cancer Center, 111 East 210th Street, Bronx, NY 10467"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leonard H.","family":"Augenlicht","sequence":"additional","affiliation":[{"name":"Department of Oncology, Montefiore Medical Center, Albert Einstein Cancer Center, 111 East 210th Street, Bronx, NY 10467"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sepehr","family":"Eskandari","sequence":"additional","affiliation":[{"name":"Biological Sciences Department, California State Polytechnic University, Pomona, CA 91768;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nancy","family":"Carrasco","sequence":"additional","affiliation":[{"name":"*Department of Molecular Pharmacology, Albert Einstein College of Medicine, Bronx, NY 10461;"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[2006,5,9]]},"reference":[{"key":"e_1_3_3_1_2","doi-asserted-by":"publisher","DOI":"10.1038\/379458a0"},{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.2000.80.3.1083"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1210\/er.2001-0029"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1038\/78630"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1210\/jcem.87.7.8797"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2004.063859"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.C400059200"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1042\/BJ20041916"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M405365200"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-05-0048"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1430846100"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-5793(98)00522-5"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1210\/me.2002-0071"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.00898"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2003-030542"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M100561200"},{"key":"e_1_3_3_17_2","first-page":"E1223","volume":"285","author":"Fanelli A.","year":"2003","unstructured":"A. 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