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PTN protected spinal motor neurons against chronic excitotoxic injury and caused increased outgrowth of motor axons out of the spinal cord explants and formation of \u201cminiventral rootlets.\u201d In neonatal mice, PTN protected the facial motor neurons against cell death induced by deprivation from target-derived growth factors. Similarly, PTN significantly enhanced regeneration of myelinated axons across a graft in the transected sciatic nerve of adult rats. Our findings suggest a neurotrophic role for PTN that may lead to previously unrecognized treatment options for motor neuron disease and motor axonal regeneration.<\/jats:p>","DOI":"10.1073\/pnas.0603243104","type":"journal-article","created":{"date-parts":[[2007,3,5]],"date-time":"2007-03-05T20:44:34Z","timestamp":1173127474000},"page":"4664-4669","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":105,"title":["Pleiotrophin is a neurotrophic factor for spinal motor neurons"],"prefix":"10.1073","volume":"104","author":[{"given":"Ruifa","family":"Mi","sequence":"first","affiliation":[{"name":"Departments of Neurology and Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD 21287"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weiran","family":"Chen","sequence":"additional","affiliation":[{"name":"Departments of Neurology and Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD 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