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Three of four rats whose spinal cords were exposed transaxially to four 400-Gy, 0.68-mm microbeams, spaced 4 mm, and all four rats irradiated to their brains with large, 170-Gy arrays of such beams spaced 1.36 mm, all observed for 7 months, showed no paralysis or behavioral changes. We then used an interlacing geometry in which two such arrays at a 90\u00b0 angle produced the equivalent of a contiguous beam in the target volume only. By using this approach, we produced 90-, 120-, and 150-Gy 3.4 \u00d7 3.4 \u00d7 3.4 mm\n                    <jats:sup>3<\/jats:sup>\n                    exposures in the rat brain. MRIs performed 6 months later revealed focal damage within the target volume at the 120- and 150-Gy doses but no apparent damage elsewhere at 120 Gy. Monte Carlo calculations indicated a 30-\u03bcm dose falloff (80\u201320%) at the edge of the target, which is much less than the 2- to 5-mm value for conventional radiotherapy and radiosurgery. These findings strongly suggest potential application of interlaced microbeams to treat tumors or to ablate nontumorous abnormalities with minimal damage to surrounding normal tissue.\n                  <\/jats:p>","DOI":"10.1073\/pnas.0603567103","type":"journal-article","created":{"date-parts":[[2006,6,7]],"date-time":"2006-06-07T20:39:13Z","timestamp":1149712753000},"page":"9709-9714","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":204,"title":["Interlaced x-ray microplanar beams: A radiosurgery approach with clinical potential"],"prefix":"10.1073","volume":"103","author":[{"given":"F. 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