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Consequently, lenticular levels of vitamin C and its oxidation products were 5- to 15-fold elevated, resulting in a highly compressed aging process and accelerated formation of several protein-bound advanced Maillard reaction products identical with those of aging human lens proteins. These data strongly implicate vitamin C in lens crystallin aging and may serve as a model for protein aging in other tissues particularly rich in vitamin C, such as the hippocampal neurons and the adrenal gland. The hSVCT2 mouse is expected to facilitate the search for drugs that inhibit damage by vitamin C oxidation products.<\/jats:p>","DOI":"10.1073\/pnas.0605101103","type":"journal-article","created":{"date-parts":[[2006,10,30]],"date-time":"2006-10-30T20:48:28Z","timestamp":1162241308000},"page":"16912-16917","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":93,"title":["Vitamin C mediates chemical aging of lens crystallins by the Maillard reaction in a humanized mouse model"],"prefix":"10.1073","volume":"103","author":[{"given":"Xingjun","family":"Fan","sequence":"first","affiliation":[{"name":"*Departments of Pathology and Biochemistry, Case Western Reserve University, Cleveland, OH 44106-7288;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lixing W.","family":"Reneker","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, University of Missouri, Columbia, MO 65212; 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