{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,25]],"date-time":"2026-10-25T18:46:43Z","timestamp":1792954003788,"version":"4.5.0"},"reference-count":60,"publisher":"National Academy of Sciences","issue":"18","license":[{"start":{"date-parts":[[2007,10,25]],"date-time":"2007-10-25T00:00:00Z","timestamp":1193270400000},"content-version":"vor","delay-in-days":177,"URL":"http:\/\/www.pnas.org\/site\/misc\/userlicense.xhtml"}],"content-domain":{"domain":["www.pnas.org"],"crossmark-restriction":true},"short-container-title":["Proc. Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2007,5]]},"abstract":"<jats:p>\n                    The serine threonine kinase\n                    <jats:italic>Akt1<\/jats:italic>\n                    has been implicated in the control of cellular metabolism, survival and growth. Here, disruption of the ubiquitously expressed member of the\n                    <jats:italic>Akt<\/jats:italic>\n                    family of genes,\n                    <jats:italic>Akt1<\/jats:italic>\n                    , in the mouse demonstrates a requirement for\n                    <jats:italic>Akt1<\/jats:italic>\n                    in ErbB2-induced mammary tumorigenesis.\n                    <jats:italic>Akt1 deficiency<\/jats:italic>\n                    delayed tumor growth and reduced lung metastases, correlating with a reduction in phosphorylation of the\n                    <jats:italic>Akt1<\/jats:italic>\n                    target, tuberous sclerosis 2 (TSC2) at Ser-939.\n                    <jats:italic>Akt1<\/jats:italic>\n                    -deficient mammary epithelial tumor cells (MEC) were reduced in size and proliferative capacity, with reduced cyclin D1 and p27\n                    <jats:sup>KIP1<\/jats:sup>\n                    abundance.\n                    <jats:italic>Akt1<\/jats:italic>\n                    deficiency abrogated the oncogene-induced changes in polarization of MEC in three-dimensional culture and reverted oncogene-induced relocalization of the phosphorylated ezrin\u2013radixin\u2013moesin proteins.\n                    <jats:italic>Akt1<\/jats:italic>\n                    increased MEC migration across an endothelial cell barrier, enhancing the persistence of migratory directionality. An unbiased proteomic analysis demonstrated\n                    <jats:italic>Akt1<\/jats:italic>\n                    mediated MEC migration through paracrine signaling via induction of expression and secretion of CXCL16 and MIP1\u03b3.\n                    <jats:italic>Akt1<\/jats:italic>\n                    governs MEC polarity, migratory directionality and breast cancer onset induced by ErbB2\n                    <jats:italic>in vivo<\/jats:italic>\n                    .\n                  <\/jats:p>","DOI":"10.1073\/pnas.0605874104","type":"journal-article","created":{"date-parts":[[2007,4,26]],"date-time":"2007-04-26T01:32:36Z","timestamp":1177551156000},"page":"7438-7443","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":170,"title":["Akt1 governs breast cancer progression\n                    <i>in vivo<\/i>"],"prefix":"10.1073","volume":"104","author":[{"given":"Xiaoming","family":"Ju","sequence":"first","affiliation":[{"name":"Departments of *Cancer Biology and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sanjay","family":"Katiyar","sequence":"additional","affiliation":[{"name":"Departments of *Cancer Biology and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chenguang","family":"Wang","sequence":"additional","affiliation":[{"name":"Departments of *Cancer Biology and"},{"name":"Medical Oncology, Kimmel Cancer Center, Thomas Jefferson University, 233 South 10th Street, Philadelphia, PA 19107;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manran","family":"Liu","sequence":"additional","affiliation":[{"name":"Departments of *Cancer Biology and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuanmao","family":"Jiao","sequence":"additional","affiliation":[{"name":"Departments of *Cancer Biology and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shengwen","family":"Li","sequence":"additional","affiliation":[{"name":"Departments of *Cancer Biology and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Zhou","sequence":"additional","affiliation":[{"name":"Departments of *Cancer Biology and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacob","family":"Turner","sequence":"additional","affiliation":[{"name":"Lombardi Comprehensive Cancer Center, Georgetown University Medical Center, Research Building, 3970 Reservoir Road NW, Washington, DC 20057; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael P.","family":"Lisanti","sequence":"additional","affiliation":[{"name":"Departments of *Cancer Biology and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert G.","family":"Russell","sequence":"additional","affiliation":[{"name":"Lombardi Comprehensive Cancer Center, Georgetown University Medical Center, Research Building, 3970 Reservoir Road NW, Washington, DC 20057; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susette C.","family":"Mueller","sequence":"additional","affiliation":[{"name":"Lombardi Comprehensive Cancer Center, Georgetown University Medical Center, Research Building, 3970 Reservoir Road NW, Washington, DC 20057; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Ojeifo","sequence":"additional","affiliation":[{"name":"Lombardi Comprehensive Cancer Center, Georgetown University Medical Center, Research Building, 3970 Reservoir Road NW, Washington, DC 20057; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William S.","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Genetics, M\/C 669, University of Illinois at Chicago, 900 South Ashland, Chicago, IL 60607"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nissim","family":"Hay","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Genetics, M\/C 669, University of Illinois at Chicago, 900 South Ashland, Chicago, IL 60607"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard G.","family":"Pestell","sequence":"additional","affiliation":[{"name":"Departments of *Cancer Biology and"},{"name":"Medical Oncology, Kimmel Cancer Center, Thomas Jefferson University, 233 South 10th Street, Philadelphia, PA 19107;"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[2007,5]]},"reference":[{"key":"e_1_3_4_1_2","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.19.8.5800"},{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.1093\/emboj\/16.10.2783"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.275.5300.661"},{"key":"e_1_3_4_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2004.11.014"},{"key":"e_1_3_4_5_2","doi-asserted-by":"publisher","DOI":"10.1006\/excr.2000.5130"},{"key":"e_1_3_4_6_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.93.8.3636"},{"key":"e_1_3_4_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0955-0674(98)80149-X"},{"key":"e_1_3_4_8_2","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.20.2.672-683.2000"},{"key":"e_1_3_4_9_2","doi-asserted-by":"publisher","DOI":"10.1038\/35060032"},{"key":"e_1_3_4_10_2","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.21.6.2203-2212.2001"},{"key":"e_1_3_4_11_2","first-page":"114","volume":"6","author":"Wilbur DC","year":"1993","unstructured":"DC Wilbur, GH Barrows Mod Pathol 6, 114\u2013120 (1993).","journal-title":"Mod Pathol"},{"key":"e_1_3_4_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(02)01001-2"},{"key":"e_1_3_4_13_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.emboj.7600323"},{"key":"e_1_3_4_14_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.C200510200"},{"key":"e_1_3_4_15_2","doi-asserted-by":"publisher","DOI":"10.1038\/ncb840"},{"key":"e_1_3_4_16_2","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.200405130"},{"key":"e_1_3_4_17_2","doi-asserted-by":"publisher","DOI":"10.1101\/gad.13.22.2905"},{"key":"e_1_3_4_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccr.2005.08.008"},{"key":"e_1_3_4_19_2","first-page":"589","volume":"61","author":"Tanno S","year":"2001","unstructured":"S Tanno, Y Mitsuuchi, DA Altomare, GH Xiao, JR Testa Cancer Res 61, 589\u2013593 (2001).","journal-title":"Cancer Res"},{"key":"e_1_3_4_20_2","doi-asserted-by":"publisher","DOI":"10.1096\/fj.01-0217"},{"key":"e_1_3_4_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.devcel.2005.08.001"},{"key":"e_1_3_4_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2005.10.033"},{"key":"e_1_3_4_23_2","doi-asserted-by":"publisher","DOI":"10.1101\/gad.913901"},{"key":"e_1_3_4_24_2","doi-asserted-by":"publisher","DOI":"10.1091\/mbc.02-06-0101"},{"key":"e_1_3_4_25_2","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.02124-05"},{"key":"e_1_3_4_26_2","doi-asserted-by":"publisher","DOI":"10.1091\/mbc.02-07-0102"},{"key":"e_1_3_4_27_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.274.11.7341"},{"key":"e_1_3_4_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)81959-5"},{"key":"e_1_3_4_29_2","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.00268-06"},{"key":"e_1_3_4_30_2","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-06-1596"},{"key":"e_1_3_4_31_2","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.01061-06"},{"key":"e_1_3_4_32_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V99.12.4434"},{"key":"e_1_3_4_33_2","doi-asserted-by":"publisher","DOI":"10.1038\/70293"},{"key":"e_1_3_4_34_2","doi-asserted-by":"publisher","DOI":"10.1038\/ncb1094"},{"key":"e_1_3_4_35_2","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.22.3.901-915.2002"},{"key":"e_1_3_4_36_2","doi-asserted-by":"publisher","DOI":"10.1038\/377539a0"},{"key":"e_1_3_4_37_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1046-2023(03)00032-X"},{"key":"e_1_3_4_38_2","doi-asserted-by":"publisher","DOI":"10.1101\/gad.1089403"},{"key":"e_1_3_4_39_2","doi-asserted-by":"publisher","DOI":"10.1242\/dev.126.23.5365"},{"key":"e_1_3_4_40_2","doi-asserted-by":"publisher","DOI":"10.1101\/gad.13.24.3244"},{"key":"e_1_3_4_41_2","doi-asserted-by":"publisher","DOI":"10.1006\/dbio.2000.9680"},{"key":"e_1_3_4_42_2","doi-asserted-by":"publisher","DOI":"10.1002\/bies.10021"},{"key":"e_1_3_4_43_2","doi-asserted-by":"publisher","DOI":"10.1038\/385537a0"},{"key":"e_1_3_4_44_2","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-03-3465"},{"key":"e_1_3_4_45_2","doi-asserted-by":"publisher","DOI":"10.1006\/bbrc.1996.1280"},{"key":"e_1_3_4_46_2","doi-asserted-by":"publisher","DOI":"10.1038\/ncb839"},{"key":"e_1_3_4_47_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0511342103"},{"key":"e_1_3_4_48_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.86.8.892"},{"key":"e_1_3_4_49_2","doi-asserted-by":"publisher","DOI":"10.1038\/79738"},{"key":"e_1_3_4_50_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)80438-9"},{"key":"e_1_3_4_51_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.2005.03123.x"},{"key":"e_1_3_4_52_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.172.6.3678"},{"key":"e_1_3_4_53_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.172.10.6362"},{"key":"e_1_3_4_54_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.21301"},{"key":"e_1_3_4_55_2","first-page":"65","volume":"14","author":"Wagsater D","year":"2004","unstructured":"D Wagsater, A Hugander, J Dimberg Int J Mol Med 14, 65\u201369 (2004).","journal-title":"Int J Mol Med"},{"key":"e_1_3_4_56_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2005-01-0428"},{"key":"e_1_3_4_57_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M311660200"},{"key":"e_1_3_4_58_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M109062200"},{"key":"e_1_3_4_59_2","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-03-0527"},{"key":"e_1_3_4_60_2","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.25.11.4591-4601.2005"}],"container-title":["Proceedings of the National Academy of Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pnas.org\/doi\/pdf\/10.1073\/pnas.0605874104","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,4,25]],"date-time":"2022-04-25T23:21:58Z","timestamp":1650928918000},"score":1,"resource":{"primary":{"URL":"https:\/\/pnas.org\/doi\/full\/10.1073\/pnas.0605874104"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,5]]},"references-count":60,"journal-issue":{"issue":"18","published-print":{"date-parts":[[2007,5]]}},"alternative-id":["10.1073\/pnas.0605874104"],"URL":"https:\/\/doi.org\/10.1073\/pnas.0605874104","relation":{},"ISSN":["0027-8424","1091-6490"],"issn-type":[{"value":"0027-8424","type":"print"},{"value":"1091-6490","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,5]]},"assertion":[{"value":"2006-07-14","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2007-05-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}