{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T13:23:42Z","timestamp":1791897822261,"version":"4.3.4"},"reference-count":34,"publisher":"National Academy of Sciences","issue":"1","content-domain":{"domain":["www.pnas.org"],"crossmark-restriction":true},"short-container-title":["Proc. Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2007,1,2]]},"abstract":"<jats:p>\n                    The early appearance of serotonin and its receptors during prenatal development, together with the many effects serotonin exerts during CNS morphogenesis, strongly suggest that serotonin influences the development and maturation of the mammalian brain before it becomes a neuromodulator\/neurotransmitter. Sites of early serotonin biosynthesis, however, have not been detected in mouse embryos or extraembryonic structures, suggesting that the main source of serotonin could be of maternal origin. This hypothesis was tested by using knockout mice lacking the\n                    <jats:italic>tph1<\/jats:italic>\n                    gene, which is responsible for the synthesis of peripheral serotonin. Genetic crosses were performed to compare the phenotype of pups born from homozygous and heterozygous mothers. Observations provide the first clear evidence that (\n                    <jats:italic>i<\/jats:italic>\n                    ) maternal serotonin is involved in the control of morphogenesis during developmental stages that precede the appearance of serotonergic neurons and (\n                    <jats:italic>ii<\/jats:italic>\n                    ) serotonin is critical for normal murine development. Most strikingly, the phenotype of\n                    <jats:italic>tph1<\/jats:italic>\n                    \u2212\/\u2212 embryos depends more on the maternal genotype than on that of the concepti. Consideration of the maternal genotype may thus help to clarify the influence of other genes in complex diseases, such as mental illness.\n                  <\/jats:p>","DOI":"10.1073\/pnas.0606722104","type":"journal-article","created":{"date-parts":[[2006,12,20]],"date-time":"2006-12-20T20:35:02Z","timestamp":1166646902000},"page":"329-334","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":345,"title":["Maternal serotonin is crucial for murine embryonic development"],"prefix":"10.1073","volume":"104","author":[{"given":"Francine","family":"C\u00f4t\u00e9","sequence":"first","affiliation":[{"name":"*Universit\u00e9 Pierre et Marie Curie, Laboratoire de G\u00e9n\u00e9tique Mol\u00e9culaire de la Neurotransmission et des Processus Neurod\u00e9g\u00e9n\u00e9ratifs, Centre National de la Recherche Scientifique, Unit\u00e9 Mixte de Recherche 7091, H\u00f4pital de la Piti\u00e9 Salp\u00eatri\u00e8re, B\u00e2timent CERVI, 83, Boulevard de 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