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Transplantation of embryonic day 42 spleen tissue into hemophilic SCID mice led to complete alleviation of hemophilia within 2\u20133 months after transplant, as demonstrated by tail bleeding and by assays for factor VIII blood levels. These results provide a proof of principle to the concept that transplantation of a fetal spleen, obtained from a developmental stage before the appearance of T cells, could provide a novel treatment modality for genetic deficiencies of an enzyme or a factor that can be replaced by the growing spleen tissue.<\/jats:p>","DOI":"10.1073\/pnas.0607012103","type":"journal-article","created":{"date-parts":[[2006,12,6]],"date-time":"2006-12-06T01:04:16Z","timestamp":1165367056000},"page":"19075-19080","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":25,"title":["Correction of hemophilia as a proof of concept for treatment of monogenic diseases by fetal spleen transplantation"],"prefix":"10.1073","volume":"103","author":[{"given":"Anna","family":"Aronovich","sequence":"first","affiliation":[{"name":"*Department of Immunology, The Weizmann Institute of Science, Rehovot 76100, 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