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We demonstrate that the supernumerary teeth develop by a renewal process where new signaling centers, the enamel knots, bud off from the existing dental epithelium. The basic aspects of the unlocked tooth renewal can be reproduced with a computer model on tooth development by increasing the intrinsic level of activator production, supporting the role of \u03b2-catenin pathway as an upstream activator of enamel knot formation. These results may implicate Wnt signaling in tooth renewal, a capacity that was all but lost when mammals evolved progressively more complicated tooth shapes.<\/jats:p>","DOI":"10.1073\/pnas.0607289103","type":"journal-article","created":{"date-parts":[[2006,11,22]],"date-time":"2006-11-22T20:44:17Z","timestamp":1164228257000},"page":"18627-18632","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":352,"title":["Continuous tooth generation in mouse is induced by activated epithelial Wnt\/\u03b2-catenin signaling"],"prefix":"10.1073","volume":"103","author":[{"given":"Elina","family":"J\u00e4rvinen","sequence":"first","affiliation":[{"name":"*Developmental Biology Program, Institute of Biotechnology, Viikki Biocenter, P.O. 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