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In Ngb-overexpressing transgenic mice compared with wild-type littermates, the volume of cerebral infarcts after occlusion of the middle cerebral artery was reduced by \u224830%, and the volume of myocardial infarcts produced by occlusion of the left anterior descending coronary artery was reduced by \u224825%. Ngb overexpression was associated with enhanced expression of endothelial nitric oxide synthase in vascular endothelial cells. These findings extend prior evidence for cytoprotection by Ngb and suggest both direct (parenchymatous) and indirect (vasomotor) protective mechanisms.<\/jats:p>","DOI":"10.1073\/pnas.0607497103","type":"journal-article","created":{"date-parts":[[2006,11,13]],"date-time":"2006-11-13T20:38:56Z","timestamp":1163450336000},"page":"17944-17948","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":194,"title":["Neuroglobin-overexpressing transgenic mice are resistant to cerebral and myocardial ischemia"],"prefix":"10.1073","volume":"103","author":[{"given":"Adil A.","family":"Khan","sequence":"first","affiliation":[{"name":"Buck Institute for Age Research, Novato, CA 94945"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaoming","family":"Wang","sequence":"additional","affiliation":[{"name":"Buck Institute for Age Research, Novato, CA 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