{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T15:40:25Z","timestamp":1781106025648,"version":"3.54.1"},"reference-count":36,"publisher":"National Academy of Sciences","issue":"7","content-domain":{"domain":["www.pnas.org"],"crossmark-restriction":true},"short-container-title":["Proc. Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2007,2,13]]},"abstract":"<jats:p>\n                    Fetal loss in animals and humans is frequently associated with inflammatory conditions. D6 is a promiscuous chemokine receptor with decoy function, expressed in lymphatic endothelium, that recognizes and targets to degradation most inflammatory CC chemokines. Here, we report that D6 is expressed in placenta on invading extravillous trophoblasts and on the apical side of syncytiotrophoblast cells, at the very interface between maternal blood and fetus. Exposure of D6\n                    <jats:sup>\u2212\/\u2212<\/jats:sup>\n                    pregnant mice to LPS or antiphospholipid autoantibodies results in higher levels of inflammatory CC chemokines and increased leukocyte infiltrate in placenta, causing an increased rate of fetal loss, which is prevented by blocking inflammatory chemokines. Thus, the promiscuous decoy receptor for inflammatory CC chemokines D6 plays a nonredundant role in the protection against fetal loss caused by systemic inflammation and antiphospholipid antibodies.\n                  <\/jats:p>","DOI":"10.1073\/pnas.0607514104","type":"journal-article","created":{"date-parts":[[2007,2,5]],"date-time":"2007-02-05T20:50:25Z","timestamp":1170708625000},"page":"2319-2324","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":154,"title":["Protection against inflammation- and autoantibody-caused fetal loss by the chemokine decoy receptor D6"],"prefix":"10.1073","volume":"104","author":[{"given":"Yeny","family":"Martinez de la Torre","sequence":"first","affiliation":[{"name":"*Istituto Clinico Humanitas, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), Rozzano, 20089 Milan, Italy;"},{"name":"Institute of General Pathology, University of Milan, 20133 Milan, Italy;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chiara","family":"Buracchi","sequence":"additional","affiliation":[{"name":"*Istituto Clinico Humanitas, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), Rozzano, 20089 Milan, Italy;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena M.","family":"Borroni","sequence":"additional","affiliation":[{"name":"*Istituto Clinico Humanitas, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), Rozzano, 20089 Milan, Italy;"},{"name":"Institute of General Pathology, University of Milan, 20133 Milan, Italy;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jana","family":"Dupor","sequence":"additional","affiliation":[{"name":"Institute of General Pathology, University of Milan, 20133 Milan, Italy;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raffaella","family":"Bonecchi","sequence":"additional","affiliation":[{"name":"*Istituto Clinico Humanitas, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), Rozzano, 20089 Milan, Italy;"},{"name":"Institute of General Pathology, University of Milan, 20133 Milan, Italy;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuela","family":"Nebuloni","sequence":"additional","affiliation":[{"name":"Pathology Unit, L. Sacco Institute of Medical Science, University of Milan, 20157 Milan, Italy;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabio","family":"Pasqualini","sequence":"additional","affiliation":[{"name":"*Istituto Clinico Humanitas, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), Rozzano, 20089 Milan, Italy;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Doni","sequence":"additional","affiliation":[{"name":"*Istituto Clinico Humanitas, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), Rozzano, 20089 Milan, Italy;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eleonora","family":"Lauri","sequence":"additional","affiliation":[{"name":"Pathology Unit, L. Sacco Institute of Medical Science, University of Milan, 20157 Milan, Italy;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chiara","family":"Agostinis","sequence":"additional","affiliation":[{"name":"Department of Physiology and Pathology, University of Trieste, 34127 Trieste, Italy;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberta","family":"Bulla","sequence":"additional","affiliation":[{"name":"Department of Physiology and Pathology, University of Trieste, 34127 Trieste, Italy;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donald N.","family":"Cook","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Pulmonary and Critical Care Medicine, Duke University Medical Center, Durham, NC 27710;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bodduluri","family":"Haribabu","sequence":"additional","affiliation":[{"name":"The James Graham Brown Cancer Center, University of Louisville Health Sciences Center, Louisville, KY 40202;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierluigi","family":"Meroni","sequence":"additional","affiliation":[{"name":"**Allergy, Clinical Immunology, and Rheumatology Unit, Istituto Auxologico Italiano, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), University of Milan, 21049 Milan, Italy;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Rukavina","sequence":"additional","affiliation":[{"name":"Department of Physiology and Immunology, University of Rijeka, 51000 Rijeka, Croatia; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luca","family":"Vago","sequence":"additional","affiliation":[{"name":"Pathology Unit, L. Sacco Institute of Medical Science, University of Milan, 20157 Milan, Italy;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Tedesco","sequence":"additional","affiliation":[{"name":"Department of Physiology and Pathology, University of Trieste, 34127 Trieste, Italy;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annunciata","family":"Vecchi","sequence":"additional","affiliation":[{"name":"*Istituto Clinico Humanitas, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), Rozzano, 20089 Milan, Italy;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sergio A.","family":"Lira","sequence":"additional","affiliation":[{"name":"Immunobiology Center, Mount Sinai School of Medicine, New York, NY 10029"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Massimo","family":"Locati","sequence":"additional","affiliation":[{"name":"*Istituto Clinico Humanitas, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), Rozzano, 20089 Milan, Italy;"},{"name":"Institute of General Pathology, University of Milan, 20133 Milan, Italy;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alberto","family":"Mantovani","sequence":"additional","affiliation":[{"name":"*Istituto Clinico Humanitas, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), Rozzano, 20089 Milan, Italy;"},{"name":"Institute of General Pathology, University of Milan, 20133 Milan, Italy;"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[2007,2,13]]},"reference":[{"key":"e_1_3_4_1_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199802123380706"},{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.iy.12.040194.003113"},{"key":"e_1_3_4_3_2","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/S0031-6997(24)01439-X","volume":"52","author":"Murphy PM","year":"2000","unstructured":"PM Murphy, M Baggiolini, IF Charo, CA Hebert, R Horuk, K Matsushima, LH Miller, JJ Oppenheim, CA Power Pharmacol Rev 52, 145\u2013176 (2000).","journal-title":"Pharmacol Rev"},{"key":"e_1_3_4_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cytogfr.2005.05.003"},{"key":"e_1_3_4_5_2","doi-asserted-by":"publisher","DOI":"10.1038\/nri1964"},{"key":"e_1_3_4_6_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.172.8.4972"},{"key":"e_1_3_4_7_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M400363200"},{"key":"e_1_3_4_8_2","doi-asserted-by":"publisher","DOI":"10.1091\/mbc.e03-09-0634"},{"key":"e_1_3_4_9_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.170.5.2279"},{"key":"e_1_3_4_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9440(10)64035-7"},{"key":"e_1_3_4_11_2","doi-asserted-by":"publisher","DOI":"10.1002\/eji.200526114"},{"key":"e_1_3_4_12_2","doi-asserted-by":"publisher","DOI":"10.1038\/ni1182"},{"key":"e_1_3_4_13_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.272.51.32078"},{"key":"e_1_3_4_14_2","doi-asserted-by":"publisher","DOI":"10.1089\/dna.1997.16.1249"},{"key":"e_1_3_4_15_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1521-4141(199903)29:03<733::AID-IMMU733>3.0.CO;2-C"},{"key":"e_1_3_4_16_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.170.1.158"},{"key":"e_1_3_4_17_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.308.6924.295"},{"key":"e_1_3_4_18_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI25536"},{"key":"e_1_3_4_19_2","doi-asserted-by":"publisher","DOI":"10.1189\/jlb.1005586"},{"key":"e_1_3_4_20_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.174.1.485"},{"key":"e_1_3_4_21_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199707173370303"},{"key":"e_1_3_4_22_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra002974"},{"key":"e_1_3_4_23_2","doi-asserted-by":"publisher","DOI":"10.1191\/0961203304lu2001oa"},{"key":"e_1_3_4_24_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI20645"},{"key":"e_1_3_4_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1471-4906(01)01941-X"},{"key":"e_1_3_4_26_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.8332913"},{"key":"e_1_3_4_27_2","doi-asserted-by":"publisher","DOI":"10.1023\/A:1015463130306"},{"key":"e_1_3_4_28_2","doi-asserted-by":"crossref","first-page":"3099","DOI":"10.4049\/jimmunol.144.8.3099","volume":"144","author":"Holmes CH","year":"1990","unstructured":"CH Holmes, KL Simpson, SD Wainwright, CG Tate, JM Houlihan, IH Sawyer, IP Rogers, FA Spring, DJ Anstee, MJ Tanner J Immunol 144, 3099\u20133105 (1990).","journal-title":"J Immunol"},{"key":"e_1_3_4_29_2","doi-asserted-by":"publisher","DOI":"10.1038\/nri722"},{"key":"e_1_3_4_30_2","doi-asserted-by":"publisher","DOI":"10.1006\/excr.1993.1139"},{"key":"e_1_3_4_31_2","doi-asserted-by":"crossref","first-page":"3615","DOI":"10.4049\/jimmunol.152.7.3615","volume":"152","author":"Sozzani S","year":"1994","unstructured":"S Sozzani, D Zhou, M Locati, M Rieppi, P Proost, M Magazin, N Vita, J van Damme, A Mantovani J Immunol 152, 3615\u20133622 (1994).","journal-title":"J Immunol"},{"key":"e_1_3_4_32_2","unstructured":"Gazzetta Ufficiale 1992"},{"key":"e_1_3_4_33_2","unstructured":"Official Journal of European Communites 1987"},{"key":"e_1_3_4_34_2","volume-title":"Guide for the Care and Use of Laboratory Animals","year":"1996","unstructured":"Guide for the Care and Use of Laboratory Animals (Natl Acad Press, Washington, DC, 1996)."},{"key":"e_1_3_4_35_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.88.8.3069"},{"key":"e_1_3_4_36_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3083.1995.tb03588.x"}],"container-title":["Proceedings of the National Academy of Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pnas.org\/doi\/pdf\/10.1073\/pnas.0607514104","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,1,13]],"date-time":"2025-01-13T10:27:06Z","timestamp":1736764026000},"score":1,"resource":{"primary":{"URL":"https:\/\/pnas.org\/doi\/full\/10.1073\/pnas.0607514104"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,2,13]]},"references-count":36,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2007,2,13]]}},"alternative-id":["10.1073\/pnas.0607514104"],"URL":"https:\/\/doi.org\/10.1073\/pnas.0607514104","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.1065768.523892","asserted-by":"object"},{"id-type":"doi","id":"10.3410\/f.1065768.518696","asserted-by":"object"}]},"ISSN":["0027-8424","1091-6490"],"issn-type":[{"value":"0027-8424","type":"print"},{"value":"1091-6490","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,2,13]]},"assertion":[{"value":"2006-08-29","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2007-02-13","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}