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Furthermore, the minima for all effects fall in a relatively narrow range of the dose-rate logarithms. Because the only mechanism common to all of these phenomena is the double-strand break (DSB) in DNA, we refer to our previous analysis of the endogenous production of DSBs, from which we concluded that \u224850 endogenous DSBs occur per cell cycle, although most are repaired without error. Comparison then reveals that their rate of production falls within the range of minima for the several end points pursuant to radiation-induced DSBs. We conclude that the results reflect a physiological principle whereby signals originating from induced DSBs elicit responses of maximal effectiveness when they are produced at a rate near that of the production of endogenous DSBs. We refer to this principle as \u201csignaling resonance.\u201d<\/jats:p>","DOI":"10.1073\/pnas.0607995103","type":"journal-article","created":{"date-parts":[[2006,11,8]],"date-time":"2006-11-08T20:40:17Z","timestamp":1163018417000},"page":"17874-17879","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":63,"title":["Radiation dose-rate effects, endogenous DNA damage, and signaling resonance"],"prefix":"10.1073","volume":"103","author":[{"given":"Michael M.","family":"Vilenchik","sequence":"first","affiliation":[{"name":"*The Sally Balin Medical Center, 110 Chesley Drive, Media, PA 19063; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alfred G.","family":"Knudson","sequence":"additional","affiliation":[{"name":"Division of Population Science, Fox Chase Cancer Center, 333 Cottman Avenue, Philadelphia, PA 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