{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T10:09:48Z","timestamp":1792145388931,"version":"4.4.0"},"reference-count":51,"publisher":"National Academy of Sciences","issue":"8","content-domain":{"domain":["www.pnas.org"],"crossmark-restriction":true},"short-container-title":["Proc. Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2007,2,20]]},"abstract":"<jats:p>\n                    Mutations in the human methyl-CpG-binding protein gene\n                    <jats:italic>MECP2<\/jats:italic>\n                    cause the neurological disorder Rett syndrome and some cases of X-linked mental retardation (XLMR). We report that MeCP2 interacts with ATRX, a SWI2\/SNF2 DNA helicase\/ATPase that is mutated in ATRX syndrome (\u03b1-thalassemia\/mental retardation, X-linked). MeCP2 can recruit the helicase domain of ATRX to heterochromatic foci in living mouse cells in a DNA methylation-dependent manner. Also, ATRX localization is disrupted in neurons of\n                    <jats:italic>Mecp2<\/jats:italic>\n                    -null mice. Point mutations within the methylated DNA-binding domain of MeCP2 that cause Rett syndrome or X-linked mental retardation inhibit its interaction with ATRX\n                    <jats:italic>in vitro<\/jats:italic>\n                    and its localization\n                    <jats:italic>in vivo<\/jats:italic>\n                    without affecting methyl-CpG binding. We propose that disruption of the MeCP2\u2013ATRX interaction leads to pathological changes that contribute to mental retardation.\n                  <\/jats:p>","DOI":"10.1073\/pnas.0608056104","type":"journal-article","created":{"date-parts":[[2007,2,12]],"date-time":"2007-02-12T20:37:47Z","timestamp":1171312667000},"page":"2709-2714","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":236,"title":["Interaction between chromatin proteins MECP2 and ATRX is disrupted by mutations that cause inherited mental retardation"],"prefix":"10.1073","volume":"104","author":[{"given":"Xinsheng","family":"Nan","sequence":"first","affiliation":[{"name":"*Wellcome Trust Centre for Cell Biology, University of Edinburgh, The King's Buildings, Edinburgh EH9 3JR, United Kingdom;"},{"name":"Molecular Medicine Centre 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