{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T03:25:18Z","timestamp":1791429918705,"version":"4.3.3"},"reference-count":42,"publisher":"National Academy of Sciences","issue":"48","content-domain":{"domain":["www.pnas.org"],"crossmark-restriction":true},"short-container-title":["Proc. Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2006,11,28]]},"abstract":"<jats:p>\n                    Rett syndrome (RTT), a postnatal neurodevelopmental disorder, is caused by mutations in the methyl-CpG-binding protein 2 (\n                    <jats:italic>MECP2<\/jats:italic>\n                    ) gene. Children with RTT display cognitive and motor abnormalities as well as autistic features. We studied mice bearing a truncated\n                    <jats:italic>Mecp2<\/jats:italic>\n                    allele (\n                    <jats:italic>\n                      Mecp2\n                      <jats:sup>308\/Y<\/jats:sup>\n                    <\/jats:italic>\n                    mice) and found evidence of increased anxiety-like behavior and an abnormal stress response as evidenced by elevated serum corticosterone levels. We found increased corticotropin-releasing hormone (\n                    <jats:italic>Crh<\/jats:italic>\n                    ) gene expression in the paraventricular nucleus of the hypothalamus, the central amygdala, and the bed nucleus of the stria terminalis. Finally, we discovered that MeCP2 binds the\n                    <jats:italic>Crh<\/jats:italic>\n                    promoter, which is enriched for methylated CpG dinucleotides. In contrast, the MeCP2\n                    <jats:sup>308<\/jats:sup>\n                    protein was not detected at the\n                    <jats:italic>Crh<\/jats:italic>\n                    promoter. This study identifies\n                    <jats:italic>Crh<\/jats:italic>\n                    as a target of MeCP2 and implicates\n                    <jats:italic>Crh<\/jats:italic>\n                    overexpression in the development of specific features of the\n                    <jats:italic>\n                      Mecp2\n                      <jats:sup>308\/Y<\/jats:sup>\n                    <\/jats:italic>\n                    mouse, thereby providing opportunities for clinical investigation and therapeutic intervention in RTT.\n                  <\/jats:p>","DOI":"10.1073\/pnas.0608702103","type":"journal-article","created":{"date-parts":[[2006,11,15]],"date-time":"2006-11-15T23:22:22Z","timestamp":1163632942000},"page":"18267-18272","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":217,"title":["Enhanced anxiety and stress-induced corticosterone release are associated with increased\n                    <i>Crh<\/i>\n                    expression in a mouse model of Rett syndrome"],"prefix":"10.1073","volume":"103","author":[{"given":"Bryan E.","family":"McGill","sequence":"first","affiliation":[{"name":"*Department of Neuroscience,"},{"name":"Medical Scientist Training Program,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sharyl F.","family":"Bundle","sequence":"additional","affiliation":[{"name":"Department of Molecular and Human Genetics,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Murat B.","family":"Yaylaoglu","sequence":"additional","affiliation":[{"name":"Verna and Marrs McLean Department of Biochemistry and Molecular Biology,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James P.","family":"Carson","sequence":"additional","affiliation":[{"name":"Verna and Marrs McLean Department of Biochemistry and Molecular Biology,"},{"name":"National Center for Macromolecular 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