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In addition, blockade of this nAChR subtype reduces the number of choline acetyltransferase-positive cells, macrophages, and lymphocytes at the site of injury. Chronic neuropathic pain is estimated to affect up to 8% of the world's population; the numerous analgesic compounds currently available are largely ineffective and act through a small number of pharmacological mechanisms. Our findings not only suggest a molecular mechanism for the treatment of neuropathic pain but also demonstrate the involvement of \u03b19\u03b110 nAChRs in the pathophysiology of peripheral nerve injury.<\/jats:p>","DOI":"10.1073\/pnas.0608715103","type":"journal-article","created":{"date-parts":[[2006,11,13]],"date-time":"2006-11-13T20:38:56Z","timestamp":1163450336000},"page":"17880-17884","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":208,"title":["Molecular mechanism for analgesia involving specific antagonism of \u03b19\u03b110 nicotinic acetylcholine receptors"],"prefix":"10.1073","volume":"103","author":[{"given":"Michelle","family":"Vincler","sequence":"first","affiliation":[{"name":"*Department of Anesthesiology, Wake Forest University School of Medicine, Medical Center Boulevard, Winston-Salem, NC 27157; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shannon","family":"Wittenauer","sequence":"additional","affiliation":[{"name":"*Department of Anesthesiology, Wake Forest University School of Medicine, Medical Center Boulevard, Winston-Salem, NC 27157; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renee","family":"Parker","sequence":"additional","affiliation":[{"name":"*Department of Anesthesiology, Wake Forest University School of Medicine, Medical Center Boulevard, Winston-Salem, NC 27157; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Ellison","sequence":"additional","affiliation":[{"name":"Departments of \u2020Biology and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Baldomero M.","family":"Olivera","sequence":"additional","affiliation":[{"name":"Departments of \u2020Biology and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. 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