{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T07:08:35Z","timestamp":1791443315518,"version":"4.3.3"},"reference-count":35,"publisher":"National Academy of Sciences","issue":"13","content-domain":{"domain":["www.pnas.org"],"crossmark-restriction":true},"short-container-title":["Proc. Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2007,3,27]]},"abstract":"<jats:p>\n                    Chromobox 7 (CBX7) is a chromobox family protein and a component of the Polycomb repressive complex 1 (PRC1) that extends the lifespan of cultured epithelial cells and can act independently of BMI-1 to repress the\n                    <jats:italic>INK4a\/ARF<\/jats:italic>\n                    tumor suppressor locus. To determine whether CBX7 might be oncogenic, we examined its expression pattern in a range of normal human tissues and tumor samples. CBX7 was expressed at high levels in germinal center lymphocytes and germinal center-derived follicular lymphomas, where elevated expression correlated with high c-Myc expression and a more advanced tumor grade. By targeting Cbx7 expression to the lymphoid compartment in mice, we showed that Cbx7 can initiate T cell lymphomagenesis and cooperate with c-Myc to produce highly aggressive B cell lymphomas. Furthermore, Cbx7 repressed transcription from the\n                    <jats:italic>Ink4a\/Arf<\/jats:italic>\n                    locus and acted epistatically to the Arf-p53 pathway during tumorigenesis. These data identify CBX7 as a chromobox protein causally linked to cancer development and may help explain the low frequency of\n                    <jats:italic>INK4a\/ARF<\/jats:italic>\n                    mutations observed in human follicular lymphoma.\n                  <\/jats:p>","DOI":"10.1073\/pnas.0608721104","type":"journal-article","created":{"date-parts":[[2007,3,20]],"date-time":"2007-03-20T20:20:54Z","timestamp":1174422054000},"page":"5389-5394","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":158,"title":["Role of the chromobox protein CBX7 in lymphomagenesis"],"prefix":"10.1073","volume":"104","author":[{"given":"Clare L.","family":"Scott","sequence":"first","affiliation":[{"name":"*Cold Spring Harbor Laboratory and"},{"name":"Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria 3050, Australia;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00e9sus","family":"Gil","sequence":"additional","affiliation":[{"name":"*Cold Spring Harbor Laboratory and"},{"name":"Medical Research Council Clinical Sciences Centre, London W12 ONN, United Kingdom;"},{"name":"Cancer Research UK, London Research Institute, London WC2A 3PX, United Kingdom;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eva","family":"Hernando","sequence":"additional","affiliation":[{"name":"Memorial Sloan\u2013Kettering Cancer Center, New York, NY 10021;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julie","family":"Teruya-Feldstein","sequence":"additional","affiliation":[{"name":"Memorial Sloan\u2013Kettering Cancer Center, New York, NY 10021;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masako","family":"Narita","sequence":"additional","affiliation":[{"name":"*Cold Spring Harbor Laboratory and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dolores","family":"Mart\u00ednez","sequence":"additional","affiliation":[{"name":"Cancer Research UK, London Research Institute, London WC2A 3PX, United Kingdom;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tapio","family":"Visakorpi","sequence":"additional","affiliation":[{"name":"University of Tampere and Tampere University Hospital, Tampere 33520, Finland; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Mu","sequence":"additional","affiliation":[{"name":"*Cold Spring Harbor Laboratory and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos","family":"Cordon-Cardo","sequence":"additional","affiliation":[{"name":"Memorial Sloan\u2013Kettering Cancer Center, New York, NY 10021;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gordon","family":"Peters","sequence":"additional","affiliation":[{"name":"Cancer Research UK, London Research Institute, London WC2A 3PX, United Kingdom;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Beach","sequence":"additional","affiliation":[{"name":"**Institute of Cell and Molecular Science, London SE16 4TL, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Scott W.","family":"Lowe","sequence":"additional","affiliation":[{"name":"*Cold Spring Harbor Laboratory and"},{"name":"Howard Hughes Medical Institute, Cold Spring Harbor, NY 11724;"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[2007,3,27]]},"reference":[{"key":"e_1_3_4_1_2","doi-asserted-by":"publisher","DOI":"10.1101\/gad.1200204"},{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1063127"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1076997"},{"key":"e_1_3_4_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0959-437X(03)00108-4"},{"key":"e_1_3_4_5_2","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddi111"},{"key":"e_1_3_4_6_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature01572"},{"key":"e_1_3_4_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2004.08.005"},{"key":"e_1_3_4_8_2","doi-asserted-by":"publisher","DOI":"10.1089\/dna.2005.24.117"},{"key":"e_1_3_4_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(91)90383-A"},{"key":"e_1_3_4_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(91)90382-9"},{"key":"e_1_3_4_11_2","first-page":"2409","volume":"61","author":"Bea S","year":"2001","unstructured":"S Bea, F Tort, M Pinyol, X Puig, L Hernandez, S Hernandez, PL Fernandez, M van Lohuizen, D Colomer, E Campo Cancer Res 61, 2409\u20132412 (2001).","journal-title":"Cancer Res"},{"key":"e_1_3_4_12_2","doi-asserted-by":"publisher","DOI":"10.1101\/gad.13.20.2678"},{"key":"e_1_3_4_13_2","doi-asserted-by":"publisher","DOI":"10.1038\/16476"},{"key":"e_1_3_4_14_2","first-page":"3161","volume":"8","author":"Haupt Y","year":"1993","unstructured":"Y Haupt, ML Bath, AW Harris, JM Adams Oncogene 8, 3161\u20133164 (1993).","journal-title":"Oncogene"},{"key":"e_1_3_4_15_2","doi-asserted-by":"publisher","DOI":"10.1038\/35096061"},{"key":"e_1_3_4_16_2","doi-asserted-by":"publisher","DOI":"10.1038\/ncb1077"},{"key":"e_1_3_4_17_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0401994101"},{"key":"e_1_3_4_18_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.211566398"},{"key":"e_1_3_4_19_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2005.26.856"},{"key":"e_1_3_4_20_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1208735"},{"key":"e_1_3_4_21_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature03203"},{"key":"e_1_3_4_22_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.132253599"},{"key":"e_1_3_4_23_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2002-07-2119"},{"key":"e_1_3_4_24_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1201262"},{"key":"e_1_3_4_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)81079-X"},{"key":"e_1_3_4_26_2","doi-asserted-by":"publisher","DOI":"10.1038\/318533a0"},{"key":"e_1_3_4_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(02)00734-1"},{"key":"e_1_3_4_28_2","doi-asserted-by":"publisher","DOI":"10.1101\/gad.13.20.2658"},{"key":"e_1_3_4_29_2","doi-asserted-by":"publisher","DOI":"10.1101\/gad.13.20.2670"},{"key":"e_1_3_4_30_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0301-472X(00)00620-2"},{"key":"e_1_3_4_31_2","doi-asserted-by":"publisher","DOI":"10.1038\/374724a0"},{"key":"e_1_3_4_32_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V91.12.4677"},{"key":"e_1_3_4_33_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V82.8.2289.2289"},{"key":"e_1_3_4_34_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.leu.2403801"},{"key":"e_1_3_4_35_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1476-5586(04)80047-2"}],"container-title":["Proceedings of the National Academy of Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pnas.org\/doi\/pdf\/10.1073\/pnas.0608721104","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,4,12]],"date-time":"2022-04-12T15:09:02Z","timestamp":1649776142000},"score":1,"resource":{"primary":{"URL":"https:\/\/pnas.org\/doi\/full\/10.1073\/pnas.0608721104"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,3,27]]},"references-count":35,"journal-issue":{"issue":"13","published-print":{"date-parts":[[2007,3,27]]}},"alternative-id":["10.1073\/pnas.0608721104"],"URL":"https:\/\/doi.org\/10.1073\/pnas.0608721104","relation":{},"ISSN":["0027-8424","1091-6490"],"issn-type":[{"value":"0027-8424","type":"print"},{"value":"1091-6490","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,3,27]]},"assertion":[{"value":"2006-10-04","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2007-03-27","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}