{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T11:30:53Z","timestamp":1791286253932,"version":"4.1.0"},"reference-count":29,"publisher":"National Academy of Sciences","issue":"51","content-domain":{"domain":["www.pnas.org"],"crossmark-restriction":true},"short-container-title":["Proc. Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2006,12,19]]},"abstract":"<jats:p>\n                    Neural stem cells and progenitors in the developing brain must choose between proliferation with renewal and differentiation. Defects in navigating this choice can result in malformations or cancers, but the genetic mechanisms that shape this choice are not fully understood. We show by positional cloning that the 30-zinc finger transcription factor Zfp423 (OAZ) is required for patterning the development of neuronal and glial precursors in the developing brain, particularly in midline structures. Mutation of\n                    <jats:italic>Zfp423<\/jats:italic>\n                    results in loss of the corpus callosum, reduction of hippocampus, and a malformation of the cerebellum reminiscent of human Dandy\u2013Walker patients. Within the cerebellum,\n                    <jats:italic>Zfp423<\/jats:italic>\n                    is expressed in both ventricular and external germinal zones. Loss of\n                    <jats:italic>Zfp423<\/jats:italic>\n                    results in diminished proliferation by granule cell precursors in the external germinal layer, especially near the midline, and abnormal differentiation and migration of ventricular zone-derived neurons and Bergmann glia.\n                  <\/jats:p>","DOI":"10.1073\/pnas.0609184103","type":"journal-article","created":{"date-parts":[[2006,12,6]],"date-time":"2006-12-06T21:10:49Z","timestamp":1165439449000},"page":"19424-19429","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":84,"title":["<i>Zfp423<\/i>\n                    controls proliferation and differentiation of neural precursors in cerebellar vermis formation"],"prefix":"10.1073","volume":"103","author":[{"given":"Wendy A.","family":"Alcaraz","sequence":"first","affiliation":[{"name":"*Biomedical Sciences Graduate Program,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David A.","family":"Gold","sequence":"additional","affiliation":[{"name":"*Biomedical Sciences Graduate Program,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric","family":"Raponi","sequence":"additional","affiliation":[{"name":"Department of Medicine, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter M.","family":"Gent","sequence":"additional","affiliation":[{"name":"*Biomedical Sciences Graduate Program,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dorothy","family":"Concepcion","sequence":"additional","affiliation":[{"name":"Department of Medicine, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruce A.","family":"Hamilton","sequence":"additional","affiliation":[{"name":"*Biomedical Sciences Graduate Program,"},{"name":"Department of Medicine, and"},{"name":"Department of Cellular and Molecular Medicine and Rebecca and John Moores University of California at San Diego Cancer Center, University of California at San Diego School of Medicine, 9500 Gilman Drive, La Jolla, CA 92093-0644"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[2006,12,19]]},"reference":[{"key":"e_1_3_5_1_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-003-0199-9"},{"key":"e_1_3_5_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/ng1420"},{"key":"e_1_3_5_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature01865"},{"key":"e_1_3_5_4_2","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.18.11.6447"},{"key":"e_1_3_5_5_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.17-11-04159.1997"},{"key":"e_1_3_5_6_2","doi-asserted-by":"publisher","DOI":"10.1242\/dev.01009"},{"key":"e_1_3_5_7_2","doi-asserted-by":"publisher","DOI":"10.1242\/dev.00215"},{"key":"e_1_3_5_8_2","doi-asserted-by":"publisher","DOI":"10.1242\/dev.126.23.5285"},{"key":"e_1_3_5_9_2","doi-asserted-by":"publisher","DOI":"10.1242\/dev.00840"},{"key":"e_1_3_5_10_2","doi-asserted-by":"publisher","DOI":"10.1242\/dev.02437"},{"key":"e_1_3_5_11_2","doi-asserted-by":"publisher","DOI":"10.1534\/genetics.104.029843"},{"key":"e_1_3_5_12_2","doi-asserted-by":"publisher","DOI":"10.1038\/nn1576"},{"key":"e_1_3_5_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)81561-5"},{"key":"e_1_3_5_14_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1207452"},{"key":"e_1_3_5_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(03)00769-4"},{"key":"e_1_3_5_16_2","author":"Gold DA","year":"2006","unstructured":"DA Gold, PM Gent, BA Hamilton Brain Res, in press. 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