{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T03:27:21Z","timestamp":1790393241062,"version":"4.1.0"},"reference-count":45,"publisher":"National Academy of Sciences","issue":"3","content-domain":{"domain":["www.pnas.org"],"crossmark-restriction":true},"short-container-title":["Proc. Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2007,1,16]]},"abstract":"<jats:p>\n                    Autoimmune polyendocrine syndrome type 1 (APS1) is a rare autosomal recessive disorder caused by mutations in the autoimmune regulator (\n                    <jats:italic>AIRE<\/jats:italic>\n                    ) gene. High titer autoantibodies (Aabs) toward intracellular enzymes are a hallmark for APS1 and serve as diagnostic markers and predictors for disease manifestations. In this study, we aimed to identify pituitary autoantigens in patients with APS1. A pituitary cDNA expression library was screened with APS1 sera and a tudor domain containing protein 6 (TDRD6) cDNA clone was isolated. Positive immunoreactivity against\n                    <jats:italic>in vitro<\/jats:italic>\n                    translated TDRD6 fragments was shown in 42\/86 (49%) APS1 patients but not in patients with other autoimmune diseases or in healthy controls. By using immunohistochemistry, sera from 3\/6 APS1 patients with growth hormone (GH) deficiency showed immunostaining of a small number of guinea pig anterior pituitary cells, and 40\u201350% of these cells were GH-positive. No such immunostaining was seen with sera from healthy controls. The APS1 Aab-positive, GH-negative cells may represent a novel subpopulation of anterior pituitary cells. In addition, 4\/6 patient sera showed staining of a fiber-plexus in the pituitary intermediate lobe recognizing enzymes of monoamine and GABA synthesis. Thus, we have identified TDRD6 as a major autoantigen in APS1 patients and shown that several sera from GH-deficient patients stain specific cell populations and nerves in the pituitary gland.\n                  <\/jats:p>","DOI":"10.1073\/pnas.0610070104","type":"journal-article","created":{"date-parts":[[2007,1,10]],"date-time":"2007-01-10T20:43:18Z","timestamp":1168461798000},"page":"949-954","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":86,"title":["Pituitary autoantibodies in autoimmune polyendocrine syndrome type 1"],"prefix":"10.1073","volume":"104","author":[{"given":"Sophie","family":"Bensing","sequence":"first","affiliation":[{"name":"*Department of Molecular Medicine and Surgery, Karolinska Institutet, Karolinska University Hospital, 171 76 Stockholm, Sweden;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sergue\u00ef O.","family":"Fetissov","sequence":"additional","affiliation":[{"name":"Department of Neuroscience, Karolinska Institutet, 171 77 Stockholm, Sweden;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan","family":"Mulder","sequence":"additional","affiliation":[{"name":"Department of Neuroscience, Karolinska Institutet, 171 77 Stockholm, Sweden;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaakko","family":"Perheentupa","sequence":"additional","affiliation":[{"name":"Hospital for Children and Adolescents, Helsinki University Hospital, 00029, Helsinki, Finland;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan","family":"Gustafsson","sequence":"additional","affiliation":[{"name":"Department of Women's and Children's Health, Uppsala University, 751 85 Uppsala, Sweden;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eystein S.","family":"Husebye","sequence":"additional","affiliation":[{"name":"**Institute of Medicine, University of Bergen, and Department of Medicine, Haukeland University Hospital, 5021 Bergen, Norway;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mikael","family":"Oscarson","sequence":"additional","affiliation":[{"name":"*Department of Molecular Medicine and Surgery, Karolinska Institutet, Karolinska University Hospital, 171 76 Stockholm, Sweden;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olov","family":"Ekwall","sequence":"additional","affiliation":[{"name":"Department of Women's and Children's Health, Uppsala University, 751 85 Uppsala, Sweden;"},{"name":"Department of Medical Sciences, Uppsala University, 751 85 Uppsala, Sweden; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patricia A.","family":"Crock","sequence":"additional","affiliation":[{"name":"Department of Paediatric Endocrinology, The John Hunter Children's Hospital, Newcastle, New South Wales 2310, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomas","family":"H\u00f6kfelt","sequence":"additional","affiliation":[{"name":"Department of Neuroscience, Karolinska Institutet, 171 77 Stockholm, Sweden;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna-Lena","family":"Hulting","sequence":"additional","affiliation":[{"name":"*Department of Molecular Medicine and Surgery, Karolinska Institutet, Karolinska University Hospital, 171 76 Stockholm, Sweden;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olle","family":"K\u00e4mpe","sequence":"additional","affiliation":[{"name":"Department of Medical Sciences, Uppsala University, 751 85 Uppsala, Sweden; and"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[2007,1,16]]},"reference":[{"key":"e_1_3_5_1_2","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1038\/ng1297-393","volume":"17","author":"Nagamine K","year":"1997","unstructured":"K Nagamine, P Peterson, HS Scott, J Kudoh, S Minoshima, M Heino, KJ Krohn, MD Lalioti, PE Mullis, SE Antonarakis, et al. Nat Genet 17, 393\u2013398 (1997).","journal-title":"Nat Genet"},{"key":"e_1_3_5_2_2","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1038\/ng1297-399","volume":"17","year":"1997","unstructured":"Nat Genet 17, 399\u2013403 (1997).","journal-title":"Nat Genet"},{"key":"e_1_3_5_3_2","doi-asserted-by":"crossref","first-page":"1395","DOI":"10.1126\/science.1075958","volume":"298","author":"Anderson MS","year":"2002","unstructured":"MS Anderson, ES Venanzi, L Klein, Z Chen, SP Berzins, SJ Turley, H von Boehmer, R Bronson, A Dierich, C Benoist, et al. Science 298, 1395\u20131401 (2002).","journal-title":"Science"},{"key":"e_1_3_5_4_2","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1038\/ni906","volume":"4","author":"Liston A","year":"2003","unstructured":"A Liston, S Lesage, J Wilson, L Peltonen, CC Goodnow Nat Immunol 4, 350\u2013354 (2003).","journal-title":"Nat Immunol"},{"key":"e_1_3_5_5_2","doi-asserted-by":"crossref","first-page":"1015","DOI":"10.1084\/jem.20040581","volume":"200","author":"Liston A","year":"2004","unstructured":"A Liston, DH Gray, S Lesage, AL Fletcher, J Wilson, KE Webster, HS Scott, RL Boyd, L Peltonen, CC Goodnow J Exp Med 200, 1015\u20131026 (2004).","journal-title":"J Exp Med"},{"key":"e_1_3_5_6_2","doi-asserted-by":"crossref","first-page":"1049","DOI":"10.1210\/jcem.83.4.4682","volume":"83","author":"Betterle C","year":"1998","unstructured":"C Betterle, NA Greggio, M Volpato J Clin Endocrinol Metab 83, 1049\u20131055 (1998).","journal-title":"J Clin Endocrinol Metab"},{"key":"e_1_3_5_7_2","doi-asserted-by":"crossref","first-page":"1559","DOI":"10.1016\/0140-6736(92)91829-W","volume":"339","author":"Winqvist O","year":"1992","unstructured":"O Winqvist, FA Karlsson, O K\u00e4mpe Lancet 339, 1559\u20131562 (1992).","journal-title":"Lancet"},{"key":"e_1_3_5_8_2","doi-asserted-by":"crossref","first-page":"8626","DOI":"10.1073\/pnas.92.19.8626","volume":"92","author":"Rorsman F","year":"1995","unstructured":"F Rorsman, ES Husebye, O Winqvist, E Bj\u00f6rk, FA Karlsson, O K\u00e4mpe Proc Natl Acad Sci USA 92, 8626\u20138629 (1995).","journal-title":"Proc Natl Acad Sci USA"},{"key":"e_1_3_5_9_2","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/S0140-6736(97)11050-9","volume":"352","author":"Ekwall O","year":"1998","unstructured":"O Ekwall, H Hedstrand, L Grimelius, J Haavik, J Perheentupa, J Gustafsson, E Husebye, O K\u00e4mpe, F Rorsman Lancet 352, 279\u2013283 (1998).","journal-title":"Lancet"},{"key":"e_1_3_5_10_2","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1006\/bbrc.1999.1945","volume":"267","author":"Hedstrand H","year":"2000","unstructured":"H Hedstrand, O Ekwall, J Haavik, E Landgren, C Betterle, J Perheentupa, J Gustafsson, E Husebye, F Rorsman, O K\u00e4mpe Biochem Biophys Res Commun 267, 456\u2013461 (2000).","journal-title":"Biochem Biophys Res Commun"},{"key":"e_1_3_5_11_2","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1210\/jc.2003-030279","volume":"89","author":"S\u00f6derbergh A","year":"2004","unstructured":"A S\u00f6derbergh, AG Myhre, O Ekwall, G Gebre-Medhin, H Hedstrand, E Landgren, A Miettinen, P Eskelin, M Halonen, T Tuomi, et al. J Clin Endocrinol Metab 89, 557\u2013562 (2004).","journal-title":"J Clin Endocrinol Metab"},{"key":"e_1_3_5_12_2","doi-asserted-by":"crossref","first-page":"1637","DOI":"10.1210\/jc.2005-0860","volume":"91","author":"Coco G","year":"2006","unstructured":"G Coco, C Dal Pra, F Presotto, MP Albergoni, C Canova, B Pedini, R Zanchetta, S Chen, J Furmaniak, B Rees Smith, et al. J Clin Endocrinol Metab 91, 1637\u20131645 (2006).","journal-title":"J Clin Endocrinol Metab"},{"key":"e_1_3_5_13_2","doi-asserted-by":"crossref","first-page":"1829","DOI":"10.1056\/NEJM199006283222601","volume":"322","author":"Ahonen P","year":"1990","unstructured":"P Ahonen, S Myllarniemi, I Sipila, J Perheentupa N Engl J Med 322, 1829\u20131836 (1990).","journal-title":"N Engl J Med"},{"key":"e_1_3_5_14_2","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1007\/BF03345481","volume":"22","author":"Franzese A","year":"1999","unstructured":"A Franzese, G Valerio, S Di Maio, MP Iannucci, A Bloise, A Tenore J Endocrinol Invest 22, 66\u201369 (1999).","journal-title":"J Endocrinol Invest"},{"key":"e_1_3_5_15_2","first-page":"844","volume":"84","author":"Ward L","year":"1999","unstructured":"L Ward, J Paquette, E Seidman, C Huot, F Alvarez, P Crock, E Delvin, O K\u00e4mpe, C Deal J Clin Endocrinol Metab 84, 844\u2013852 (1999).","journal-title":"J Clin Endocrinol Metab"},{"key":"e_1_3_5_16_2","first-page":"765","volume":"21","author":"Al-Herbish AS","year":"2000","unstructured":"AS Al-Herbish, JD Bailey, SW Kooh Saudi Med J 21, 765\u2013768 (2000).","journal-title":"Saudi Med J"},{"key":"e_1_3_5_17_2","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1016\/S0889-8529(01)00013-5","volume":"31","author":"Perheentupa J","year":"2002","unstructured":"J Perheentupa Endocrinol Metab Clin North Am 31, 295\u2013320 (2002).","journal-title":"Endocrinol Metab Clin North Am"},{"key":"e_1_3_5_18_2","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1111\/j.1445-5994.1980.tb04974.x","volume":"10","author":"Clifton-Bligh P","year":"1980","unstructured":"P Clifton-Bligh, C Lee, H Smith, S Posen Aust N Z J Med 10, 548\u2013551 (1980).","journal-title":"Aust N Z J Med"},{"key":"e_1_3_5_19_2","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1136\/bjo.68.5.367","volume":"68","author":"Hung SO","year":"1984","unstructured":"SO Hung, A Patterson Br J Ophtalmol 68, 367\u2013369 (1984).","journal-title":"Br J Ophtalmol"},{"key":"e_1_3_5_20_2","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1111\/j.1365-2265.1986.tb01707.x","volume":"25","author":"Scherbaum WA","year":"1986","unstructured":"WA Scherbaum, JA Wass, GM Besser, GF Bottazzo, D Doniach Clin Endocrinol 25, 411\u2013420 (1986).","journal-title":"Clin Endocrinol"},{"key":"e_1_3_5_21_2","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/S0022-3476(71)80061-6","volume":"79","author":"Castells S","year":"1971","unstructured":"S Castells, S Fikrig, S Inamdar, E Orti J Pediatr 79, 72\u201379 (1971).","journal-title":"J Pediatr"},{"key":"e_1_3_5_22_2","doi-asserted-by":"crossref","first-page":"1492","DOI":"10.1001\/jama.1973.03220400030006","volume":"225","author":"Arvanitakis C","year":"1973","unstructured":"C Arvanitakis, RF Knouss J Am Med Assoc 225, 1492\u20131495 (1973).","journal-title":"J Am Med Assoc"},{"key":"e_1_3_5_23_2","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/S0140-6736(75)90004-5","volume":"2","author":"Bottazzo GF","year":"1975","unstructured":"GF Bottazzo, A Pouplard, A Florin-Christensen, D Doniach Lancet 2, 97\u2013101 (1975).","journal-title":"Lancet"},{"key":"e_1_3_5_24_2","doi-asserted-by":"crossref","first-page":"4108","DOI":"10.1210\/jc.2004-2184","volume":"90","author":"Cocco C","year":"2005","unstructured":"C Cocco, A Meloni, F Boi, G Pinna, R Possenti, S Mariotti, GL Ferri J Clin Endocrinol Metab 90, 4108\u20134111 (2005).","journal-title":"J Clin Endocrinol Metab"},{"key":"e_1_3_5_25_2","volume":"78","author":"O'Dwyer DT","year":"2007","unstructured":"DT O'Dwyer, P McElduff, P Peterson, J Perheentupa, PA Crock Acta Biomed Ateneo Parmense 78, in press. (2007).","journal-title":"Acta Biomed Ateneo Parmense"},{"key":"e_1_3_5_26_2","doi-asserted-by":"crossref","first-page":"752","DOI":"10.1210\/jc.87.2.752","volume":"87","author":"O'Dwyer DT","year":"2002","unstructured":"DT O'Dwyer, AI Smith, ML Matthew, NM Andronicos, M Ranson, PJ Robinson, PA Crock J Clin Endocrinol Metab 87, 752\u2013757 (2002).","journal-title":"J Clin Endocrinol Metab"},{"key":"e_1_3_5_27_2","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1507\/endocrj.50.697","volume":"50","author":"Tanaka S","year":"2003","unstructured":"S Tanaka, KI Tatsumi, T Takano, Y Murakami, T Takao, N Yamakita, S Tahara, A Teramoto, K Hashimoto, Y Kato, et al. Endocr J 50, 697\u2013702 (2003).","journal-title":"Endocr J"},{"key":"e_1_3_5_28_2","doi-asserted-by":"crossref","first-page":"4465","DOI":"10.1073\/pnas.012025199","volume":"99","author":"Su AI","year":"2002","unstructured":"AI Su, MP Cooke, KA Ching, Y Hakak, JR Walker, T Wiltshire, AP Orth, RG Vega, LM Sapinoso, A Moqrich, et al. Proc Natl Acad Sci USA 99, 4465\u20134470 (2002).","journal-title":"Proc Natl Acad Sci USA"},{"key":"e_1_3_5_29_2","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/S0968-0004(96)30049-2","volume":"22","author":"Ponting CP","year":"1997","unstructured":"CP Ponting Trends Biochem Sci 22, 51\u201352 (1997).","journal-title":"Trends Biochem Sci"},{"key":"e_1_3_5_30_2","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1038\/83014","volume":"8","author":"Selenko P","year":"2001","unstructured":"P Selenko, R Spranglers, G Stier, D Buhler, U Fischer, M Sattler Nat Struct Biol 8, 27\u201331 (2001).","journal-title":"Nat Struct Biol"},{"key":"e_1_3_5_31_2","doi-asserted-by":"crossref","first-page":"28476","DOI":"10.1074\/jbc.M414328200","volume":"280","author":"Cote J","year":"2005","unstructured":"J Cote, S Richard J Biol Chem 280, 28476\u201328483 (2005).","journal-title":"J Biol Chem"},{"key":"e_1_3_5_32_2","doi-asserted-by":"crossref","first-page":"652","DOI":"10.1002\/(SICI)1097-0215(19980529)76:5<652::AID-IJC7>3.0.CO;2-P","volume":"76","author":"Scanlan MJ","year":"1998","unstructured":"MJ Scanlan, YT Chen, B Williamson, AO Gure, E Stockert, JD Gordan, O Tureci, U Sahin, M Pfreundschuh, LJ Old Int J Cancer 76, 652\u2013658 (1998).","journal-title":"Int J Cancer"},{"key":"e_1_3_5_33_2","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1111\/j.1365-2265.2005.02296.x","volume":"63","author":"De Bellis A","year":"2005","unstructured":"A De Bellis, A Bizzarro, S Perrino, C Coronella, M Conte, D Pasquali, AA Sinisi, C Betterle, A Bellastella Clin Endocrinol 63, 45\u201349 (2005).","journal-title":"Clin Endocrinol"},{"key":"e_1_3_5_34_2","doi-asserted-by":"crossref","first-page":"2484","DOI":"10.1210\/jc.2006-0040","volume":"91","author":"De Bellis A","year":"2006","unstructured":"A De Bellis, M Salerno, M Conte, C Coronella, G Tirelli, M Battaglia, V Esposito, G Ruocco, G Bellastella, A Bizzarro, et al. J Clin Endocrinol Metab 91, 2484\u20132489 (2006).","journal-title":"J Clin Endocrinol Metab"},{"key":"e_1_3_5_35_2","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1007\/BF00306908","volume":"126","author":"Baumgarten HG","year":"1972","unstructured":"HG Baumgarten, A Bj\u00f6rklund, AF Holstein, A Nobin Z Zellforsch Mikrosk Anat 126, 483\u2013517 (1972).","journal-title":"Z Zellforsch Mikrosk Anat"},{"key":"e_1_3_5_36_2","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/0006-8993(73)90371-5","volume":"51","author":"Bj\u00f6rklund A","year":"1973","unstructured":"A Bj\u00f6rklund, RY Moore, A Nobin, U Stenevi Brain Res 51, 171\u2013191 (1973).","journal-title":"Brain Res"},{"key":"e_1_3_5_37_2","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1073\/pnas.79.2.675","volume":"79","author":"Oertel WH","year":"1982","unstructured":"WH Oertel, E Mugnaini, ML Tappaz, VK Weise, AL Dahl, DE Schmechel, IJ Kopin Proc Natl Acad Sci USA 79, 675\u2013679 (1982).","journal-title":"Proc Natl Acad Sci USA"},{"key":"e_1_3_5_38_2","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1159\/000123977","volume":"39","author":"Everitt BJ","year":"1984","unstructured":"BJ Everitt, T H\u00f6kfelt, JY Wu, M Goldstein Neuroendocrinology 39, 189\u2013191 (1984).","journal-title":"Neuroendocrinology"},{"key":"e_1_3_5_39_2","doi-asserted-by":"crossref","first-page":"1943","DOI":"10.1210\/endo-112-6-1943","volume":"112","author":"Friedman E","year":"1983","unstructured":"E Friedman, DT Krieger, E Mezey, C Leranth, MJ Brownstein, M Palkovits Endocrinology 112, 1943\u20131947 (1983).","journal-title":"Endocrinology"},{"key":"e_1_3_5_40_2","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/0168-0102(94)90156-2","volume":"21","author":"Vanhatalo S","year":"1994","unstructured":"S Vanhatalo, S Soinila Neurosci Res 21, 143\u2013149 (1994).","journal-title":"Neurosci Res"},{"key":"e_1_3_5_41_2","doi-asserted-by":"crossref","first-page":"1457","DOI":"10.1177\/40.10.1527370","volume":"40","author":"Adams JC","year":"1992","unstructured":"JC Adams J Histochem Cytochem 40, 1457\u20131463 (1992).","journal-title":"J Histochem Cytochem"},{"key":"e_1_3_5_42_2","first-page":"399","volume":"1","author":"Coons AH","year":"1958","unstructured":"AH Coons Gen Cytochem Methods 1, 399\u2013422 (1958).","journal-title":"Gen Cytochem Methods"},{"key":"e_1_3_5_43_2","doi-asserted-by":"crossref","first-page":"113","DOI":"10.3109\/08916939409009539","volume":"19","author":"Falorni A","year":"1994","unstructured":"A Falorni, CE Grubin, I Takei, A Shimada, A Kasuga, T Maruyama, Y Ozawa, T Kasatani, T Saruta, L Li, et al. Autoimmunity 19, 113\u2013125 (1994).","journal-title":"Autoimmunity"},{"key":"e_1_3_5_44_2","first-page":"147","volume":"82","author":"Husebye ES","year":"1997","unstructured":"ES Husebye, G Gebre-Medhin, T Tuomi, J Perheentupa, M Landin-Olsson, J Gustafsson, F Rorsman, O K\u00e4mpe J Clin Endocrinol Metab 82, 147\u2013150 (1997).","journal-title":"J Clin Endocrinol Metab"},{"key":"e_1_3_5_45_2","doi-asserted-by":"crossref","first-page":"3389","DOI":"10.1093\/nar\/25.17.3389","volume":"25","author":"Altschul SF","year":"1997","unstructured":"SF Altschul, TL Madden, AA Schaffer, J Zhang, Z Zhang, W Miller, DJ Lipman Nucleic Acids Res 25, 3389\u20133402 (1997).","journal-title":"Nucleic Acids Res"}],"container-title":["Proceedings of the National Academy of Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pnas.org\/doi\/pdf\/10.1073\/pnas.0610070104","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,6,7]],"date-time":"2022-06-07T02:13:31Z","timestamp":1654568011000},"score":1,"resource":{"primary":{"URL":"https:\/\/pnas.org\/doi\/full\/10.1073\/pnas.0610070104"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,1,16]]},"references-count":45,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2007,1,16]]}},"alternative-id":["10.1073\/pnas.0610070104"],"URL":"https:\/\/doi.org\/10.1073\/pnas.0610070104","relation":{},"ISSN":["0027-8424","1091-6490"],"issn-type":[{"value":"0027-8424","type":"print"},{"value":"1091-6490","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,1,16]]},"assertion":[{"value":"2005-10-05","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2007-01-16","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}