{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T21:27:00Z","timestamp":1791149220547,"version":"4.1.0"},"reference-count":43,"publisher":"National Academy of Sciences","issue":"2","content-domain":{"domain":["www.pnas.org"],"crossmark-restriction":true},"short-container-title":["Proc. Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2007,1,9]]},"abstract":"<jats:p>\n                    The identity of the endogenous epithelial cells in the adult lung that are responsible for normal turnover and repair after injury is still controversial. In part, this is due to a paucity of highly specific genetic lineage tools to follow efficiently the fate of the major epithelial cell populations: the basal, secretory, ciliated, neuroendocrine, and alveolar cells. As part of a program to address this problem we have used a 1-kb\n                    <jats:italic>FOXJ1<\/jats:italic>\n                    promoter to drive\n                    <jats:italic>CreER<\/jats:italic>\n                    in the ciliated cells of the embryonic and adult lung. Analysis of\n                    <jats:italic>FOXJ1<\/jats:italic>\n                    -\n                    <jats:italic>GFP<\/jats:italic>\n                    transgenic lungs shows that labeled cells appear in a proximal-distal pattern during embryogenesis and that the promoter drives expression in all ciliated cells. Using\n                    <jats:italic>FOXJ1CreER<\/jats:italic>\n                    adult mice, we have followed the fate of ciliated cells after epithelial injury by naphthalene or sulfur dioxide. From quantitative analysis and confocal microscopy we conclude that ciliated cells transiently change their morphology in response to lung injury but do not proliferate or transdifferentiate as part of the repair process.\n                  <\/jats:p>","DOI":"10.1073\/pnas.0610770104","type":"journal-article","created":{"date-parts":[[2006,12,28]],"date-time":"2006-12-28T20:24:53Z","timestamp":1167337493000},"page":"410-417","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":238,"title":["Lung development and repair: Contribution of the ciliated lineage"],"prefix":"10.1073","volume":"104","author":[{"given":"Emma L.","family":"Rawlins","sequence":"first","affiliation":[{"name":"*Department of Cell Biology, Duke University Medical Center, Durham, NC 27710; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lawrence E.","family":"Ostrowski","sequence":"additional","affiliation":[{"name":"Cystic Fibrosis\/Pulmonary Research and Treatment Center, University of North Carolina, Chapel Hill, NC 27599"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Scott H.","family":"Randell","sequence":"additional","affiliation":[{"name":"Cystic Fibrosis\/Pulmonary Research and Treatment Center, University of North Carolina, Chapel Hill, NC 27599"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brigid L. 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