{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T16:40:52Z","timestamp":1792255252873,"version":"4.4.0"},"reference-count":39,"publisher":"National Academy of Sciences","issue":"9","content-domain":{"domain":["www.pnas.org"],"crossmark-restriction":true},"short-container-title":["Proc. Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2007,2,27]]},"abstract":"\n CO\n 2<\/jats:sub>\n elicits a response from many insects, including mosquito vectors of diseases such as malaria and yellow fever, but the molecular basis of CO\n 2<\/jats:sub>\n detection is unknown in insects or other higher eukaryotes. Here we show that\n Gr21a<\/jats:italic>\n and\n Gr63a<\/jats:italic>\n , members of a large family of\n Drosophila<\/jats:italic>\n seven-transmembrane-domain chemoreceptor genes, are coexpressed in chemosensory neurons of both the larva and the adult. The two genes confer CO\n 2<\/jats:sub>\n response when coexpressed in an\n in vivo<\/jats:italic>\n expression system, the \u201cempty neuron system.\u201d The response is highly specific for CO\n 2<\/jats:sub>\n and dependent on CO\n 2<\/jats:sub>\n concentration. The response shows an equivalent dependence on the dose of\n Gr21a<\/jats:italic>\n and\n Gr63a<\/jats:italic>\n . None of 39 other chemosensory receptors confers a comparable response to CO\n 2<\/jats:sub>\n . The identification of these receptors may now allow the identification of agents that block or activate them. Such agents could affect the responses of insect pests to the humans they seek.\n <\/jats:p>","DOI":"10.1073\/pnas.0700079104","type":"journal-article","created":{"date-parts":[[2007,2,21]],"date-time":"2007-02-21T00:04:11Z","timestamp":1172016251000},"page":"3574-3578","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":481,"title":["The molecular basis of CO\n 2<\/sub>\n reception in\n Drosophila<\/i>"],"prefix":"10.1073","volume":"104","author":[{"given":"Jae Young","family":"Kwon","sequence":"first","affiliation":[{"name":"Department of Molecular, Cellular, and Developmental Biology, Yale University, New Haven, CT 06520-8103"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anupama","family":"Dahanukar","sequence":"additional","affiliation":[{"name":"Department of Molecular, Cellular, and Developmental Biology, Yale University, New Haven, CT 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