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Loss or mutation of either PC2 or its regulatory protein polycystin-1 (PC1) results in autosomal dominant polycystic kidney disease (ADPKD), characterized by cyst formation and growth and often leading to renal failure and death. Here we show that triptolide, the active diterpene in the traditional Chinese medicine\n                    <jats:italic>Lei Gong Teng<\/jats:italic>\n                    , induces Ca\n                    <jats:sup>2+<\/jats:sup>\n                    release by a PC2-dependent mechanism. Furthermore, in a murine model of ADPKD, triptolide arrests cellular proliferation and attenuates overall cyst formation by restoring Ca\n                    <jats:sup>2+<\/jats:sup>\n                    signaling in these cells. We anticipate that small molecule induction of PC2-dependent calcium release is likely to be a valid therapeutic strategy for ADPKD.\n                  <\/jats:p>","DOI":"10.1073\/pnas.0700499104","type":"journal-article","created":{"date-parts":[[2007,3,6]],"date-time":"2007-03-06T22:21:40Z","timestamp":1173219700000},"page":"4389-4394","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":204,"title":["Triptolide is a traditional Chinese medicine-derived inhibitor of polycystic kidney disease"],"prefix":"10.1073","volume":"104","author":[{"given":"Stephanie J.","family":"Leuenroth","sequence":"first","affiliation":[{"name":"Departments of *Molecular, Cellular, and Developmental Biology,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dayne","family":"Okuhara","sequence":"additional","affiliation":[{"name":"Internal Medicine,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph 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