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Genetic linkage analysis of an RCND-informative pedigree has identified a linkage group flanking\n                    <jats:italic>RCND<\/jats:italic>\n                    (CHP14-C05.377-C05.414-FH2383-C05.771-[\n                    <jats:italic>RCND<\/jats:italic>\n                    -CPH18]-C02608-\n                    <jats:italic>GLUT4<\/jats:italic>\n                    -\n                    <jats:italic>TP53<\/jats:italic>\n                    -ZuBeCa6-AHT141-FH2140-FH2594) thus localizing the disease to a small region of canine chromosome 5. The closest marker, C02608, is linked to\n                    <jats:italic>RCND<\/jats:italic>\n                    with a recombination fraction (\u03b8) of 0.016, supported by a logarithm of odds score of 16.7. C02608 and the adjacent linked markers map to a region of the canine genome corresponding to portions of human chromosomes 1p and 17p. A combination of linkage analysis and direct sequencing eliminate several likely candidate genes, including tuberous sclerosis 1 and 2 genes (\n                    <jats:italic>TSC1<\/jats:italic>\n                    and\n                    <jats:italic>TSC2<\/jats:italic>\n                    ) and the tumor suppressor gene\n                    <jats:italic>TP53.<\/jats:italic>\n                    These data suggest that RCND may be caused by a previously unidentified tumor suppressor gene and highlight the potential for canine genetics in the study of human disease predisposition.\n                  <\/jats:p>","DOI":"10.1073\/pnas.070053397","type":"journal-article","created":{"date-parts":[[2002,7,26]],"date-time":"2002-07-26T10:31:44Z","timestamp":1027679504000},"page":"4132-4137","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":80,"title":["Genetic mapping of a naturally occurring hereditary renal cancer syndrome in dogs"],"prefix":"10.1073","volume":"97","author":[{"given":"Thora J.","family":"J\u00f3nasd\u00f3ttir","sequence":"first","affiliation":[{"name":"Norwegian School of Veterinary Science, Department of Morphology, Genetics, and Aquatic Biology, Section of Genetics, Department of Morphology, Genetics, and Aquatic Biology, Section of Pathology, and Department of Small Animal Clinical Sciences, P.O. Box 8146 Dep, N-0033 Oslo, Norway; Clinical Research Division, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, D4\u2013100 Seattle, WA 98109-1024; and National Veterinary Institute, Section of Pathology, P.O. Box 8156 Dep, N-0033 Oslo,..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cathryn S.","family":"Mellersh","sequence":"additional","affiliation":[{"name":"Norwegian School of Veterinary Science, Department of Morphology, Genetics, and Aquatic Biology, Section of Genetics, Department of Morphology, Genetics, and Aquatic Biology, Section of Pathology, and Department of Small Animal Clinical Sciences, P.O. Box 8146 Dep, N-0033 Oslo, Norway; Clinical Research Division, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, D4\u2013100 Seattle, WA 98109-1024; and National Veterinary Institute, Section of Pathology, P.O. Box 8156 Dep, N-0033 Oslo,..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lars","family":"Moe","sequence":"additional","affiliation":[{"name":"Norwegian School of Veterinary Science, Department of Morphology, Genetics, and Aquatic Biology, Section of Genetics, Department of Morphology, Genetics, and Aquatic Biology, Section of Pathology, and Department of Small Animal Clinical Sciences, P.O. Box 8146 Dep, N-0033 Oslo, Norway; Clinical Research Division, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, D4\u2013100 Seattle, WA 98109-1024; and National Veterinary Institute, Section of Pathology, P.O. Box 8156 Dep, N-0033 Oslo,..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ragna","family":"Heggeb\u00f8","sequence":"additional","affiliation":[{"name":"Norwegian School of Veterinary Science, Department of Morphology, Genetics, and Aquatic Biology, Section of Genetics, Department of Morphology, Genetics, and Aquatic Biology, Section of Pathology, and Department of Small Animal Clinical Sciences, P.O. Box 8146 Dep, N-0033 Oslo, Norway; Clinical Research Division, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, D4\u2013100 Seattle, WA 98109-1024; and National Veterinary Institute, Section of Pathology, P.O. Box 8156 Dep, N-0033 Oslo,..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hans","family":"Gamlem","sequence":"additional","affiliation":[{"name":"Norwegian School of Veterinary Science, Department of Morphology, Genetics, and Aquatic Biology, Section of Genetics, Department of Morphology, Genetics, and Aquatic Biology, Section of Pathology, and Department of Small Animal Clinical Sciences, P.O. Box 8146 Dep, N-0033 Oslo, Norway; Clinical Research Division, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, D4\u2013100 Seattle, WA 98109-1024; and National Veterinary Institute, Section of Pathology, P.O. Box 8156 Dep, N-0033 Oslo,..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elaine A.","family":"Ostrander","sequence":"additional","affiliation":[{"name":"Norwegian School of Veterinary Science, Department of Morphology, Genetics, and Aquatic Biology, Section of Genetics, Department of Morphology, Genetics, and Aquatic Biology, Section of Pathology, and Department of Small Animal Clinical Sciences, P.O. Box 8146 Dep, N-0033 Oslo, Norway; Clinical Research Division, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, D4\u2013100 Seattle, WA 98109-1024; and National Veterinary Institute, Section of Pathology, P.O. 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